ArticleNeuroImage2022
Comparing myelin-sensitive magnetic resonance imaging measures and resulting g-ratios in healthy and multiple sclerosis brains.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- TAnnals of clinical and translational neurology · 2026Article
- Advances in multiscale myelin imaging: from classical histology to functional insights.Frontiers in cellular neuroscience · 2026Review
- Periventricular gradients in axonal and myelin microstructure are present in people with multiple sclerosis having low and high disability.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A critical period plasticity framework for the sensorimotor-association axis of cortical neurodevelopment.Trends in neurosciences · 2023Review
- Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis.Acta neuropathologica communications · 2023Article
- Comparing myelin-sensitive magnetic resonance imaging measures and resulting g-ratios in healthy and multiple sclerosis brains.NeuroImage · 2022Article
- Overview of myelin, major myelin lipids, and myelin-associated proteins.Frontiers in chemistry · 2022Review
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
The myelin concentration and the degree of myelination of nerve fibers can provide valuable information on the integrity of human brain tissue. Magnetic resonance imaging (MRI) of myelin-sensitive parameters can help to non-invasively evaluate demyelinating diseases such as multiple sclerosis (MS). Several different myelin-sensitive MRI methods have been proposed to determine measures of the degree of myelination, in particular the g-ratio. However, variability in underlying physical principles and different biological models influence measured myelin concentrations, and consequently g-ratio values. We therefore investigated similarities and differences between five different myelin-sensitive MRI measures and their effects on g-ratio mapping in the brains of both MS patients and healthy volunteers. We compared two different estimates of the myelin water fraction (MWF) as well as the inhomogeneous magnetization transfer ratio (ihMTR), magnetization transfer saturation (MTsat), and macromolecular tissue volume (MTV) in 13 patients with MS and 14 healthy controls. In combination with diffusion-weighted imaging, we derived g-ratio parameter maps for each of the five different myelin measures. The g-ratio values calculated from different myelin measures varied strongly, especially in MS lesions. While, compared to normal-appearing white matter, MTsat and one estimate of the MWF resulted in higher g-ratio values within lesions, ihMTR, MTV, and the second MWF estimate resulted in lower lesion g-ratio values. As myelin-sensitive measures provide rough estimates of myelin content rather than absolute myelin concentrations, resulting g-ratio values strongly depend on the utilized myelin measure and model used for g-ratio mapping. When comparing g-ratio values, it is, thus, important to utilize the same MRI methods and models or to consider methodological differences. Particular caution is necessary in pathological tissue such as MS lesions.
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Registered trials
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