Evidence map›Paper›PMID 36379408›Full record

Observational studyThe journal of allergy and clinical immunology. In practice2023

Association of Asthma With Treatments and Outcomes in Children With Critical Influenza.

Aline B Maddux, Jocelyn R Grunwell, Margaret M Newhams, Sabrina R Chen, Samantha M Olson, Natasha B Halasa, Scott L Weiss, Bria M Coates, Jennifer E Schuster, Mark W Hall and 16 more

Open access · greenAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in The journal of allergy and clinical immunology. In practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Beyond respiratory syncytial virus and rhinovirus: The other viral respiratory bandits.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review
  4. Serum leptin and adiponectin function as indicators of allergic sensitization in pediatric adenotonsillar hypertrophy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 18 institutions in 1 country.

Aline B MadduxDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colo.
Jocelyn R GrunwellDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga; Division of Critical Care Medicine, Children's Healthcare of Atlanta, Atlanta, Ga.
Margaret M NewhamsDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Mass.
Sabrina R ChenDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Mass.
Samantha M OlsonNational Center for Immunization and Respiratory Diseases, Centers for Disease Control of Prevention, Atlanta, Ga.
Natasha B HalasaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.
Scott L WeissDivision of Critical Care, Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa.
Bria M CoatesDivision of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Jennifer E SchusterDivision of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Miss.
Mark W HallDivision of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
Ryan A NofzigerDivision of Critical Care Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio.
Heidi R FloriDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, Mich.
Shira J GertzDivision of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ.
Michele KongDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Ala.
Ronald C SandersSection of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Ark.
Katherine IrbySection of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Ark.
Janet R HumeDivision of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, Minn.
Melissa L CullimoreDivision of Pediatric Critical Care, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Neb.
Steven L SheinDivision of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Neal J ThomasDepartment of Pediatrics, Penn State Hershey Children's Hospital, Penn State University College of Medicine, Hershey, Pa.
Kristen MillerDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colo.
Manish PatelNational Center for Immunization and Respiratory Diseases, Centers for Disease Control of Prevention, Atlanta, Ga.
Anne M FitzpatrickChildren's Healthcare of Atlanta, Division of Pulmonology, Cystic Fibrosis, and Sleep Medicine, Atlanta, Ga.
Wanda PhipatanakulDepartment of Pediatrics, Division of Immunology, Boston Children's Hospital, Boston, Mass.
Adrienne G RandolphDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Mass; Department of Anaesthesia, Harvard Medical School, Boston, Mass. Electronic address: Adrienne.Randolph@childrens.harvard.edu.
PALISI Pediatric Intensive Care Influenza Network Investigators
Boston Children's Hospital · USArkansas Children's Hospital · USChildren's Hospital Colorado · USNational Center for Immunization and Respiratory Diseases · USChildren's Healthcare of Atlanta · USAkron Children's Hospital · USChildren's Mercy Hospital · USC. S. Mott Children's Hospital · USLurie Children's Hospital · USNationwide Children's Hospital · USNebraska Medical Center · USPenn State Milton S. Hershey Medical Center · USRainbow Babies & Children's Hospital · USSaint Barnabas Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Minnesota Children's Hospital · USUniversity of Pennsylvania · USVanderbilt University Medical Center · US

Funding

Immunobiology of Influenza Virus-related Critical Illness in Young HostsR01AI154470 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RANDOLPH, ADRIENNE G, THOMAS, PAUL G. · 2020 to 2024
$4.7M
Airway Immune Response in Critically Ill Children-Precision Medicine in Children At Risk for Acute Respiratory Distress SyndromeK23HL151897 · NHLBI · EMORY UNIVERSITY · PI GRUNWELL, JOCELYN REBECCA · 2020 to 2024
$888k
Functional Outcomes after Prolonged Mechanical Ventilation in ChildrenK23HD096018 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MADDUX, ALINE BERNARD · 2019 to 2023
$807k
Mentored patient-oriented research in preschool wheezing disordersK24NR018866 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO · 2020 to 2024
$625k
NHLBI NIH HHS K23 HL151897NIAID NIH HHS R01 AI154470NICHD NIH HHS K23 HD096018NINR NIH HHS K24 NR018866
6 · The paper itself

Abstract

backgroundHospitalization for severe influenza infection in childhood may result in postdischarge sequelae.

objectiveTo evaluate inpatient management and postdischarge sequelae in children with critical respiratory illness owing to influenza with or without preexisting asthma.

methodsThis was a prospective, observational multicenter study of children (aged 8 months to 17 years) admitted to a pediatric intensive care or high-acuity unit (in November 2019 to April 2020) for influenza. Results were stratified by preexisting asthma. Prehospital status, hospital treatments, and outcomes were collected. Surveys at approximately 90 days after discharge evaluated postdischarge health resource use, functional status, and respiratory symptoms.

resultsA total of 165 children had influenza: 56 with preexisting asthma (33.9%) and 109 without it (66.1%; 41.1% and 39.4%, respectively, were fully vaccinated against influenza). Fifteen patients with preexisting asthma (26.7%) and 34 without it (31.1%) were intubated. More patients with versus without preexisting asthma received pharmacologic asthma treatments during hospitalization (76.7% vs 28.4%). Of 136 patients with 90-day survey data (82.4%; 46 with preexisting asthma [33.8%] and 90 without it [66.1%]), a similar proportion had an emergency department/urgent care visit (4.3% vs 6.6%) or hospital readmission (8.6% vs 3.3%) for a respiratory condition. Patients with preexisting asthma more frequently experienced asthma symptoms (78.2% vs 3.3%) and had respiratory specialist visits (52% vs 20%) after discharge. Of 109 patients without preexisting asthma, 10 reported receiving a new diagnosis of asthma (11.1%).

conclusionsRespiratory health resource use and symptoms are important postdischarge outcomes after influenza critical illness in children with and without preexisting asthma. Less than half of children were vaccinated for influenza, a tool that could mitigate critical illness and its sequelae.

Indexed as

AsthmaInfluenza, HumanAftercareChildCritical IllnessDisease ProgressionHospitalizationHumansPatient DischargeProspective StudiesAcute respiratory viral infectionAsthmaInfluenzaOutcomesPediatric intensive care unitReactive airway disease

Identifiers

PMID36379408
PMCPMC10006305
OpenAlexW4309157559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.