ReviewJournal of child psychology and psychiatry, and allied disciplines2023
Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- No evidence of parental mental health influencing children's academic achievement: a within-family study.European child & adolescent psychiatry · 2026Article
- Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status.Communications medicine · 2026Article
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- The Power to Resolve Cultural Transmission and Sibling Interaction Using Polygenic Scores.Behavior genetics · 2026Article
- RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.Genome biology · 2025Article
- In the genetics of the beholder: gene-environment interplay for internalising and externalising behaviours using polygenic scores and adolescent perceptions of parenting.European child & adolescent psychiatry · 2025Article
- Cross-Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress.Developmental psychobiology · 2025Article
- Direct and indirect genetic effects on early neurodevelopmental traits.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Intergenerational transmission of complex traits and the offspring methylome.Molecular psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.medRxiv : the preprint server for health sciences · 2023Article
- Genetic contributions of noncognitive skills to academic development.Research square · 2023Article
- Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?Translational psychiatry · 2023Article
- Why we need families in genomic research on developmental psychopathology.JCPP advances · 2023Article
- Celebrating a Century of Research in Behavioral Genetics.Behavior genetics · 2023Review
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Authors and funding
3 authors.
Funding
Abstract
Distinguishing between the effects of nature and nurture constitutes a major research goal for those interested in understanding human development. It is known, for example, that many parent traits predict mental health outcomes in children, but the causal processes underlying such associations are often unclear. Family-based quasi-experimental designs such as sibling comparison, adoption and extended family studies have been used for decades to distinguish the genetic transmission of risk from the environmental effects family members potentially have on one another. Recently, these designs have been combined with genomic data, and this combination is fuelling a range of exciting methodological advances. In this review we explore these advances - highlighting the ways in which they have been applied to date and considering what they are likely to teach us in the coming years about the aetiology and intergenerational transmission of psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.