ArticleJournal of the neurological sciences2022
Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization.
Article in Journal of the neurological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review to find link between past psychiatric history and development of long covid.BMC psychiatry · 2025Pooled it
- Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients.BMC neurology · 2025Pooled it
- Pooled it
- The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Increased incidence of mild cognitive impairment in long COVID patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Mechanisms and impact of long COVID: pathophysiology, neuropsychiatric effects and vaccination.Frontiers in immunology · 2026Review
- Persistent physical and mental health effects of COVID-19 hospitalization.Frontiers in pediatrics · 2026Article
- The association between baseline physical and mental health and the risk of postacute sequelae of COVID-19 infection.Scientific reports · 2025Article
- Subjective cognitive, psychiatric, and fatigue symptoms two years after COVID-19: A prospective longitudinal cohort study.Brain, behavior, & immunity - health · 2025Article
- Risk factors for fatigue severity in the post-COVID-19 condition: A prospective controlled cohort study of nonhospitalised adolescents and young adults.Brain, behavior, & immunity - health · 2025Article
- Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms.Molecular psychiatry · 2024Article
- Clusters of long COVID among patients hospitalized for COVID-19 in New York City.BMC public health · 2024Article
- Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models.Zoological research · 2024Review
- Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis.Translational psychiatry · 2024Article
- Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry.Journal of neurology · 2024Article
- Mechanisms of long COVID: An updated review.Chinese medical journal pulmonary and critical care medicine · 2023Review
- Long-Term Consequences of COVID-19: A 1-Year Analysis.Journal of clinical medicine · 2023Article
- Racial, ethnic, and sex disparities in the incidence and cognitive symptomology of long COVID-19.Journal of the National Medical Association · 2023Article
- Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundLimited data exists evaluating predictors of long-term outcomes after hospitalization for COVID-19.
methodsWe conducted a prospective, longitudinal cohort study of patients hospitalized for COVID-19. The following outcomes were collected at 6 and 12-months post-diagnosis: disability using the modified Rankin Scale (mRS), activities of daily living assessed with the Barthel Index, cognition assessed with the telephone Montreal Cognitive Assessment (t-MoCA), Neuro-QoL batteries for anxiety, depression, fatigue and sleep, and post-acute symptoms of COVID-19. Predictors of these outcomes, including demographics, pre-COVID-19 comorbidities, index COVID-19 hospitalization metrics, and life stressors, were evaluated using multivariable logistic regression.
resultsOf 790 COVID-19 patients who survived hospitalization, 451(57%) completed 6-month (N = 383) and/or 12-month (N = 242) follow-up, and 77/451 (17%) died between discharge and 12-month follow-up. Significant life stressors were reported in 121/239 (51%) at 12-months. In multivariable analyses, life stressors including financial insecurity, food insecurity, death of a close contact and new disability were the strongest independent predictors of worse mRS, Barthel Index, depression, fatigue, and sleep scores, and prolonged symptoms, with adjusted odds ratios ranging from 2.5 to 20.8. Other predictors of poor outcome included older age (associated with worse mRS, Barthel, t-MoCA, depression scores), baseline disability (associated with worse mRS, fatigue, Barthel scores), female sex (associated with worse Barthel, anxiety scores) and index COVID-19 severity (associated with worse Barthel index, prolonged symptoms).
conclusionsLife stressors contribute substantially to worse functional, cognitive and neuropsychiatric outcomes 12-months after COVID-19 hospitalization. Other predictors of poor outcome include older age, female sex, baseline disability and severity of index COVID-19.
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