Evidence map›Paper›PMID 36378959›Full record

ArticleScience (New York, N.Y.)2022

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease.

Fumito Endo, Atsushi Kasai, Joselyn S Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S Khakh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 328 papers.

0numbers the graph read from it
0cells of the map it votes in
328citing papers in PubMed
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

328 citing papers in PubMed, 491 citations in OpenAlex.

  1. Article
  2. Article
  3. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

268 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fumito EndoDepartment of Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4445-6707
Atsushi KasaiLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.ORCID 0000-0002-1612-3078
Joselyn S SotoDepartment of Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5869-9091
Xinzhu YuDepartment of Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1244-0110
Zhe QuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Hitoshi HashimotoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.ORCID 0000-0001-6548-4016
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-5868-348X
Riki KawaguchiCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Baljit S KhakhDepartment of Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0939-1218
University of California, Los Angeles · USCalifornia Institute of Technology · USThe University of Osaka · JP

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER · 2020 to 2026
$9.6M
Fundamental astrocyte biology in intact neural circuitsR35NS111583 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Baljit Khakh · 2019 to 2026
$7.9M
Astrocyte and neuron brain-region and compartment-specific proteome dynamics in aging and Alzheimer’s diseaseR01AG075955 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT, VOSSEL, KEITH ALAN · 2021 to 2025
$5.2M
New tools to target, identify and characterize astrocytes in the adult nervous systemR01DA047444 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRADINARU, VIVIANA, KHAKH, BALJIT · 2018 to 2020
$3.3M
NIA NIH HHS R01 AG075955NICHD NIH HHS P50 HD103557NIDA NIH HHS R01 DA047444NINDS NIH HHS R35 NS111583
6 · The paper itself

Abstract

Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the mouse central nervous system (CNS). We identified shared and region-specific astrocytic genes and functions and explored the cellular origins of their regional diversity. We identified gene networks correlated with astrocyte morphology, several of which unexpectedly contained Alzheimer's disease (AD) risk genes. CRISPR/Cas9-mediated reduction of candidate genes reduced astrocyte morphological complexity and resulted in cognitive deficits. The same genes were down-regulated in human AD, in an AD mouse model that displayed reduced astrocyte morphology, and in other human brain disorders. We thus provide comprehensive molecular data on astrocyte diversity and mechanisms across the CNS and on the molecular basis of astrocyte morphology in health and disease.

Indexed as

Alzheimer DiseaseAstrocytesCentral Nervous SystemTranscriptomeAnimalsDisease Models, AnimalHumansMice

Identifiers

PMID36378959
PMCPMC9873482
OpenAlexW4308451957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.