Evidence map›Paper›PMID 36378934›Full record

SynthesisJournal of cardiac surgery2022

Mortality after sternal reconstruction with pectoralis major flap vs omental flap for postsurgical mediastinitis: A systematic review and meta-analysis.

Gianmarco Cancelli, Talal Alzghari, Arnaldo Dimagli, Katia Audisio, Anas Dabsha, Lamia Harik, Roberto Perezgrovas Olaria, Giovanni J Soletti, Michelle Demetres, Mario Gaudino

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of cardiac surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gianmarco CancelliDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Talal AlzghariDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Arnaldo DimagliDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Katia AudisioDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Anas DabshaDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Lamia HarikDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.
Roberto Perezgrovas OlariaDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.ORCID http://orcid.org/0000-0002-3823-8861
Giovanni J SolettiDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.ORCID http://orcid.org/0000-0002-8691-5951
Michelle DemetresSamuel J. Wood Library and C.V. Starr Biomedical Information Centre, Weill Cornell Medicine, New York, New York, USA.
Mario GaudinoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.ORCID http://orcid.org/0000-0003-4680-0815
Cornell University · US

Funding

Multidisciplinary Research Training in Cardiovascular DiseaseT32HL160520 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Geoffrey S Pitt, Jonathan W. Weinsaft · 2022 to 2026
$2.0M
NHLBI NIH HHS T32 HL160520
6 · The paper itself

Abstract

backgroundDeep sternal wound infections are rare but severe complications after median sternotomy and can be managed with sternal reconstruction. The use of pectoralis major flap (PMF) has traditionally been the first-line approach for flap reconstruction but the advantage in patients' survival when compared to the omental flap (OF) transposition is still not clear. We performed a study-level meta-analysis evaluating the association of the type of flap on postoperative outcomes.

methodsA systematic search of the literature was performed to identify all studies comparing the postoperative outcomes of PMF versus OF for sternal reconstruction. The primary outcome was postoperative mortality. Secondary outcomes were the occurrence of sepsis, pneumonia, operative time, and length of stay. Binary outcomes were pooled using an inverse variance method and reported as odds ratio (OR) with corresponding 95% confidence interval (CI). Continuous outcomes were pooled using an inverse variance method and reported as standardized mean difference (SMD) with corresponding 95% CI.

resultsFour studies with a total of 528 patients were included in the analysis. Overall, 443 patients had PMF reconstruction, and 85 patients had OF reconstruction. Baseline characteristics were similar in both groups. There were no statistically significant differences between PMF patients and OF patients in mortality (OR 0.6 [0.16; 2.17]; p = .09), sepsis (OR 1.1 [0.49; 2.47]; p = .43), pneumonia (OR 0.72 [0.18; 2.8]; p = .11), length of stay (SMD -0.59 [-2.03; 0.85]; p < .01), and operative time (SMD 0.08 [-1.21; 1.57]; p < .01).

conclusionOur analysis found no association between the type of flap and postoperative mortality, the incidence of pneumonia, sepsis, operation time, and length of stay.

Indexed as

MediastinitisPectoralis MusclesHumansRetrospective StudiesSternotomySternumSurgical FlapsSurgical Wound InfectionTreatment Outcomedeep sternal wound infectionsflapsmediastinitis

Identifiers

PMID36378934
PMCPMC11973449
OpenAlexW4309438412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.