Evidence map›Paper›PMID 36378750›Full record

ArticleScience signaling2022

M

Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N Mistry, Andrew R Bottrill, Patrick M Sexton, Arthur Christopoulos and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Discovery of VU0467319: an MACS chemical neuroscience · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. New Light on Prions: Putative Role of PrPInternational journal of molecular sciences · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Louis DwomohCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-7024-6450
Mario RossiCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-7004-0225
Miriam ScarpaCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Elham KhajehaliDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Colin MolloyCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-7179-7721
Pawel HerzykCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Shailesh N MistrySchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-2252-1689
Andrew R BottrillResearch Technology Platforms, University of Warwick, School of Life Sciences, Coventry CV4 7AL, UK.ORCID 0000-0002-5182-3643
Patrick M SextonDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0001-8902-2473
Arthur ChristopoulosDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0003-4442-3294
Jeffrey ConnWarren Centre for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-2363-0323
Craig W LindsleyWarren Centre for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-0168-1445
Sophie J BradleyCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-0035-4090
Andrew B TobinCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-1807-3123
University of Glasgow · GBAustralian Research Council · AUVanderbilt University · USThe University of Melbourne · AUUniversity of Nottingham · GBUniversity of Warwick · GB

Funding

Medical Research Council MR/P016693/1Medical Research Council MR/P019366/1Wellcome Trust 201529Wellcome Trust 201529/Z/16/Z
6 · The paper itself

Abstract

Many dementias are propagated through the spread of "prion-like" misfolded proteins. This includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer's disease (AD), for which no treatments are available to slow or stop progression. The M

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesPrion DiseasesPrionsAnimalsHumansMicePathology, MolecularProteomicsReceptor, Muscarinic M1PrionsReceptor, Muscarinic M1

Identifiers

PMID36378750
PMCPMC7616172
OpenAlexW4309185540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.