Evidence map›Paper›PMID 36378689›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2022

Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study.

Jari A Laukkanen, Setor K Kunutsor, Jussi Hernesniemi, Jaakko Immonen, Markku Eskola, Francesco Zaccardi, Matti Niemelä, Timo Mäkikallio, Magnus Hagnäs, Jarkko Piuhola and 7 more

Abstract read
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Impact of Heart Failure and Chronic Kidney Disease on All-Cause Mortality in Patients Undergoing Coronary Angiography: Results From the Finnish Kardio Multicentre Registry.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2022
    Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jari A LaukkanenSchool of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3738-1586
Setor K KunutsorCentral Finland Health Care District, Department of Medicine, Jyväskylä, Finland.
Jussi HernesniemiHeart Center, Department of Cardiology, Tampere University Hospital, Tampere, Finland.
Jaakko ImmonenCentral Finland Health Care District, Department of Medicine, Jyväskylä, Finland.
Markku EskolaHeart Center, Department of Cardiology, Tampere University Hospital, Tampere, Finland.
Francesco ZaccardiCentral Finland Health Care District, Department of Medicine, Jyväskylä, Finland.
Matti NiemeläDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Timo MäkikallioDepartment of Medicine, South-Karelia Central Hospital, Lappeenranta, Finland.
Magnus HagnäsLapland Health Care District, Department of Internal Medicine, Rovaniemi, Finland.
Jarkko PiuholaDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Jukka JuvonenDepartment of Internal Medicine, Kainuu Central Hospital, Kajaani, Finland.
Jussi SiaDepartment of Cardiology, Kokkola Central Hospital, Kokkola, Finland.
Juha RummukainenDepartment of Internal Medicine, Satakunta Central Hospital, Pori, Finland.
Kari KervinenDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Juha KarvanenDepartment of Mathematics and Statistics, University of Jyvaskyla, Jyväskylä, Finland.
Kjell NikusHeart Center, Department of Cardiology, Tampere University Hospital, Tampere, Finland.
KARDIO Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed "obesity paradox"). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography.

methodsWe utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut-offs or transformed using P-splines. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for all-cause mortality.

resultsDuring a median follow-up of 4.9 years, 4688 all-cause deaths occurred. BMI was nonlinearly associated with mortality risk: compared to normal weight category (18.5-25 kg/m

conclusionsIn patients undergoing coronary angiography, underweight and obesity class III are associated with increased mortality risk, and the lowest mortality was observed in the preobesity class. It appears the obesity paradox may be present in patients who undergo invasive coronary procedures.

Indexed as

CardiologyCardiovascular DiseasesBody Mass IndexCoronary AngiographyHumansObesityRisk FactorsThinnessTreatment Outcomeangiographybody mass indexcoronary artery diseasehospital registermortality

Identifiers

PMID36378689
PMCPMC10098486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.