Evidence map›Paper›PMID 36378644›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome

Florencia Tomasina, Jennyfer Martínez, Ari Zeida, María Laura Chiribao, Verónica Demicheli, Agustín Correa, Celia Quijano, Laura Castro, Robert H Carnahan, Paige Vinson and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Nitration in cancer signaling.Redox biology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 3 countries.

Florencia TomasinaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Jennyfer MartínezDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Ari ZeidaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0003-0938-287X
María Laura ChiribaoDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Verónica DemicheliDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Agustín CorreaRecombinant Protein Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Celia QuijanoDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0001-9254-7123
Laura CastroDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-5771-7630
Robert H CarnahanVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0001-5230-1532
Paige VinsonSouthern Research, Birmingham, AL 35205.
Matt GoffVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Tracy CooperVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
W Hayes McDonaldDepartment of Biochemistry and the Proteomics Core of the Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37240.
Natalie CastellanaAbterra Biosciences, San Diego, CA 92109.
Luciana HannibalCentro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Paul T MorseCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201.ORCID 0000-0003-1530-1466
Junmei WanCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201.
Maik HüttemannCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201.
Ronald JemmersonDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455.
Lucía PiacenzaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Rafael RadiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-1114-1875
Universidad de la República de Uruguay · UYVanderbilt University Medical Center · USWayne State University · USInstitut Pasteur de Montevideo · UYSouthern Research Institute · USUniversity of Freiburg · DEUniversity of Minnesota · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Control of Cell Respiration and Apoptosis by Phosphorylation of Cytochrome cR01GM116807 · NIGMS · WAYNE STATE UNIVERSITY · PI HUETTEMANN, MAIK · 2017 to 2020
$1.5M
Valens-Poly Sequencing Polyclonal Antibodies for Drug DiscoveryR44GM103346 · NIGMS · DIGITAL PROTEOMICS LLC · PI CASTELLANA, NATALIE · 2015 to 2016
$653k
NCI NIH HHS P30 CA068485NIGMS NIH HHS R01 GM116807NIGMS NIH HHS R44 GM103346
6 · The paper itself

Abstract

Cytochrome

Indexed as

Cytochromes cHemeAmino Acid SequenceAnimalsAntibodies, MonoclonalHybridomasMelanoma, ExperimentalMiceOxidation-ReductionAntibodies, MonoclonalCytochromes cHemealternative conformationcytochrome cmonoclonal antibodyoxidationredox signaling

Identifiers

PMID36378644
PMCPMC9704708
OpenAlexW4309070845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.