ArticleJournal of the American Chemical Society2022
Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C-H Alkenylation.Organic letters · 2026Article
- Ligand-Enabled Chemo- and Regioselective Ir(I)-Catalyzed Intermolecular Hydrocarbonation of Allenes: Access to Branched Products with All-Carbon Quaternary Centers.Angewandte Chemie (International ed. in English) · 2025Article
- Substrate NOBINAc ligand affinity for PdChemical science · 2025Article
- Convenient alternative synthesis of theBeilstein journal of organic chemistry · 2025Article
- Assembly of 2-Substituted Tetrahydroquinolines fromOrganic letters · 2024Article
- Axially Chiral 2-Hydroxybiaryls by Palladium-Catalyzed Enantioselective C-H Activation.ACS catalysis · 2023Article
- A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines.Chemical science · 2023Article
- Enantioselective Total Synthesis of (-)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones.Journal of the American Chemical Society · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the first examples of the use of a new class of ligands (NOBINAc) for performing asymmetric C-H activations using palladium catalysts. These ligands combine the axial chirality of binaphthyl scaffolds with the bifunctional and bidentate coordination properties of mono-N-protected amino acids (MPAAs), which are well-known to favor Pd-promoted C-H activations via concerted metalation-deprotonation mechanisms. We demonstrate that our new ligands enable substantially higher enantioselectivities than MPAAs in the assembly of 2-benzazepines through formal (5 + 2) cycloadditions between homobenzyltriflamides or
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