Evidence map›Paper›PMID 36377945›Full record

ArticleMicrobiology spectrum2022

SourceFinder: a Machine-Learning-Based Tool for Identification of Chromosomal, Plasmid, and Bacteriophage Sequences from Assemblies.

Derya Aytan-Aktug, Vladislav Grigorjev, Judit Szarvas, Philip T L C Clausen, Patrick Munk, Marcus Nguyen, James J Davis, Frank M Aarestrup, Ole Lund

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Derya Aytan-Aktug *National Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0002-7086-8791
Vladislav Grigorjev *National Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.
Judit SzarvasNational Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0002-0720-3017
Philip T L C ClausenNational Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0002-8197-7520
Patrick MunkNational Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0001-8813-4019
Marcus NguyenConsortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0003-2591-6042
James J DavisConsortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0104-5852
Frank M AarestrupNational Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0002-7116-2723
Ole LundNational Food Institute, Technical University of Denmarkgrid.5170.3, Kongens Lyngby, Denmark.ORCID 0000-0003-1108-0491
Technical University of Denmark · DKArgonne National Laboratory · US

Funding

BIOINFORMATICS RESOURCE CENTERS FOR INFECTIOUS DISEASES: SARS-CoV-2 ACTIVITIES75N93019C00076 · NIAID · UNIVERSITY OF CHICAGO · PI STEVENS, RICK · 2019 to 2023
$32.6M
NIAID NIH HHS 75N93019C00076
6 · The paper itself

Abstract

High-throughput genome sequencing technologies enable the investigation of complex genetic interactions, including the horizontal gene transfer of plasmids and bacteriophages. However, identifying these elements from assembled reads remains challenging due to genome sequence plasticity and the difficulty in assembling complete sequences. In this study, we developed a classifier, using random forest, to identify whether sequences originated from bacterial chromosomes, plasmids, or bacteriophages. The classifier was trained on a diverse collection of 23,211 chromosomal, plasmid, and bacteriophage sequences from hundreds of bacterial species. In order to adapt the classifier to incomplete sequences, each complete sequence was subsampled into 5,000 nucleotide fragments and further subdivided into

Indexed as

BacteriophagesGenome, BacterialChromosomes, BacterialHumansMachine LearningPlasmidsassembly identificationbacteriophagechromosomemachine learningplasmidsource identification

Identifiers

PMID36377945
PMCPMC9769690
OpenAlexW4309098162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.