Evidence map›Paper›PMID 36377895›Full record

ArticlemBio2022

Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis

Ko-Wei Liu, Madeleine S Grau, Jane T Jones, Xi Wang, Elisa M Vesely, Matthew R James, Cecilia Gutierrez-Perez, Robert A Cramer, Joshua J Obar

Abstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  14. Article
  15. Article
  16. Viral reactivations and fungal infections in nonresolving acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Fungal coinfection/superinfection in COVID-19 patients in a tertiary hospital in MexicoBiomedica : revista del Instituto Nacional de Salud · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ko-Wei LiuDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0003-4110-9101
Madeleine S GrauDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jane T JonesDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Xi WangDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Elisa M VeselyDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0003-4745-9276
Matthew R JamesDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Cecilia Gutierrez-PerezDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Robert A CramerDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0001-5503-5006
Joshua J ObarDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0003-4068-7911

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
Antifungal Immunity and the Mechanism of Fungal Programmed Cell DeathR01AI139632 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CRAMER, ROBERT ANDREW, HOHL, TOBIAS M · 2019 to 2023
$3.3M
Development of an influenza A virus and Aspergillus fumigatus coinfection modelR21AI152019 · NIAID · DARTMOUTH COLLEGE · PI OBAR, JOSHUA J · 2020 to 2021
$451k
NIAID NIH HHS R21 AI152019NIAID NIH HHS T32 AI007363NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Aspergillus fumigatus is a human fungal pathogen that is most often avirulent in immunecompetent individuals because the innate immune system is efficient at eliminating fungal conidia. However, recent clinical observations have shown that severe influenza A virus (IAV) infection can lead to secondary A. fumigatus infections with high mortality. Little is currently known about how IAV infection alters the innate antifungal immune response. Here, we established a murine model of IAV-induced A. fumigatus (IAV-

Indexed as

AspergillosisInfluenza A Virus, H1N1 SubtypeSuperinfectionAnimalsAspergillusAspergillus fumigatusHumansMiceSpores, FungalZymosanZymosanantifungal immunityAspergillus fumigatushost-pathogen interactionsinfluenza A virusinnate immunityinvasive pulmonary aspergillosismonocytesneutrophilspathogenesisphagocytosisphagolysosomephagolysosome maturationsuperinfection

Identifiers

PMID36377895
PMCPMC9765436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.