Evidence map›Paper›PMID 36377886›Full record

ArticleMicrobiology spectrum2022

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO

Selvi C Ersoy, Barbara Gonçalves, Gonçalo Cavaco, Adhar C Manna, Rita G Sobral, Cynthia C Nast, Richard A Proctor, Henry F Chambers, Ambrose Cheung, Arnold S Bayer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  2. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  3. Review
  4. Defects in anaplerotic metabolism sensitizeMicrobiology spectrum · 2025
    Article
  5. Article
  6. Review
  7. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  8. Role of the NaHCOMicrobiology spectrum · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Selvi C ErsoyThe Lundquist Institute, Torrance, California, USA.ORCID 0000-0002-8792-2061
Barbara GonçalvesLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO, Applied Molecular Biosciences Unit, Department of Life Sciences, Nova School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal.
Gonçalo CavacoLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO, Applied Molecular Biosciences Unit, Department of Life Sciences, Nova School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal.
Adhar C MannaDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-4055-2489
Rita G SobralLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO, Applied Molecular Biosciences Unit, Department of Life Sciences, Nova School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal.ORCID 0000-0003-4533-7531
Cynthia C NastCedars-Sinai Medical Centergrid.50956.3f, Los Angeles, California, USA.
Richard A ProctorDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Henry F ChambersUCSF School of Medicine, San Francisco, California, USA.
Ambrose CheungDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Arnold S BayerThe Lundquist Institute, Torrance, California, USA.
Universidade Nova de Lisboa · PTDartmouth College · USCedars-Sinai Medical Center · USUniversity of California, Los Angeles · USUniversity of Wisconsin–Madison · US

Funding

Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
HHS | National Institutes of Health (NIH) 1R01-AI146078NIAID NIH HHS R01 AI146078
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard

Indexed as

Methicillin-Resistant Staphylococcus aureusSodium BicarbonateTeichoic AcidsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsCefuroximeCell WallMicrobial Sensitivity TestsMonobactamsStaphylococcus aureusAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsCefuroximeMonobactamsSodium BicarbonateTeichoic Acidsmethicillin resistancemethicillin-resistant Staphylococcus aureus (MRSA)penicillin-binding proteins (PBPs)peptidoglycan (PG)sodium bicarbonatewall teichoic acid (WTA)β-lactams

Identifiers

PMID36377886
PMCPMC9769754
OpenAlexW4309097320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.