Evidence map›Paper›PMID 36377872›Full record

ArticleJournal of virology2022

Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803.

Olivia E Harwood, Alexis J Balgeman, Abigail J Weaver, Amy L Ellis-Connell, Andrea M Weiler, Katrina N Erickson, Lea M Matschke, Athena E Golfinos, Vaiva Vezys, Pamela J Skinner and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Olivia E HarwoodDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alexis J BalgemanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Abigail J WeaverDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Amy L Ellis-ConnellDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrea M WeilerWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Katrina N EricksonWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Lea M MatschkeDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Athena E GolfinosDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vaiva VezysCenter for Immunology, Department of Microbiology and Immunology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Pamela J SkinnerDepartment of Veterinary and Biomedical Sciences, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.ORCID 0000-0003-3388-1687
Jeffrey T SafritImmunityBio, Culver City, California, USA.
Paul T EdlefsenVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-8393-8103
Matthew R ReynoldsDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Thomas C FriedrichWisconsin National Primate Research Center, Madison, Wisconsin, USA.ORCID 0000-0001-9831-6895
Shelby L O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-0183-5010
University of Wisconsin–Madison · USUniversity of Minnesota · USFred Hutch Cancer Center · USImmunityBio (United States) · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, PAUL L · 1985 to 2011
$106.7M
Evaluating immunity elicited by CD8 T Cell responses targeting invariant epitopesR01AI108415 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SHELBY L OCONNOR · 2014 to 2026
$9.5M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
NCRR NIH HHS P51 RR000167NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI108415NIDA NIH HHS 75N95020D00005NIH HHS P51 OD011106ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Vaccine strategies aimed at eliciting human immunodeficiency virus (HIV)-specific CD8

Indexed as

CD8-Positive T-LymphocytesSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsCell ProliferationMacaca mulattaRecombinant Fusion ProteinsVaccinationVaccinia virusALT-803Recombinant Fusion ProteinsSAIDS VaccinesARTheterologous prime-boost-boost vaccinationN-803nonhuman primateSIV

Identifiers

PMID36377872
PMCPMC9749465
OpenAlexW4309096709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.