Evidence map›Paper›PMID 36377867›Full record

ArticlemBio2022

Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism.

Stephen K Dolan, Andre Wijaya, Michael Kohlstedt, Lars Gläser, Paul Brear, Rafael Silva-Rocha, Christoph Wittmann, Martin Welch

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Multi-layered metabolic remodeling ofMetabolic engineering communications · 2026
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  9. Rapid dissemination of host metabolism-manipulating genes via integrative and conjugative elements.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Stephen K DolanSchool of Biological Sciences, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.ORCID 0000-0002-7391-2137
Andre WijayaCentre for Targeted Protein Degradation, University of Dundee, Dundee, Scotland, United Kingdom.
Michael KohlstedtInstitute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Lars GläserInstitute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Paul BrearDepartment of Biochemistry, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Rafael Silva-RochaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-6319-631X
Christoph WittmannInstitute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.ORCID 0000-0002-7952-985X
Martin WelchDepartment of Biochemistry, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.ORCID 0000-0003-3646-1733
Saarland University · DEUniversity of Cambridge · GBGeorgia Institute of Technology · USUniversidade de São Paulo · BRUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human pathogen Pseudomonas aeruginosa (Pa) is one of the most frequent and severe causes of nosocomial infection. This organism is also a major cause of airway infections in people with cystic fibrosis (CF). Pa is known to have a remarkable metabolic plasticity, allowing it to thrive under diverse environmental conditions and ecological niches; yet, little is known about the central metabolic pathways that sustain its growth during infection or precisely how these pathways operate. In this work, we used a combination of 'omics approaches (transcriptomics, proteomics, metabolomics, and

Indexed as

Pseudomonas aeruginosaPseudomonas InfectionsCitrate (si)-SynthaseHumansKineticsPropionatesTranscription FactorsCitrate (si)-SynthasePropionatesTranscription Factors2-methylcitrate cyclecentral metabolismenzyme promiscuitypropionate metabolismPseudomonas aeruginosaunderground metabolism

Identifiers

PMID36377867
PMCPMC9765439
OpenAlexW4309048142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.