ArticleEpilepsia2023
Contribution of the μ-opioid receptor system to affective disorders in temporal lobe epilepsy: A bidirectional relationship?
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Quality of life among patients with epilepsy in the western region of KSA: A cross-sectional study.Journal of Taibah University Medical Sciences · 2025Article
- The upside of epilepsy: Theories of an evolutionary paradox.Epilepsia open · 2025Review
- Neuropsychiatry revisited: epilepsy as the borderland between neurology and psychiatry.Frontiers in psychiatry · 2024Review
- Contribution of the μ-opioid receptor system to affective disorders in temporal lobe epilepsy: A bidirectional relationship?Epilepsia · 2023Article
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
objectiveAffective disorders are frequent comorbidities of temporal lobe epilepsy (TLE). The endogenous opioid system has been implicated in both epilepsy and affective disorders, and may play a significant role in their bidirectional relationship. In this cross-sectional study, we investigated the association between μ-opioid receptor binding and affective disorders in patients with TLE.
methodsNine patients with TLE and depression/anxiety underwent
resultsWe observed widely reduced CFN binding potential (BP) in bilateral frontal lobes and striata in patients with TLE compared to healthy controls. In the TLE group, more severe anxiety and negative affect were associated with decreased CFN BP in the posterior cingulate gyrus. SIGNIFICANCE: In patients with TLE, interictally reduced binding in the opioid system was associated with higher levels of anxiety and negative affect. We speculate that seizure-related agonist-driven desensitization and downregulation of opioid receptors could be a potential underlying pathomechanism.
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