ArticleMolecular systems biology2022
Enhancing nutritional niche and host defenses by modifying the gut microbiome.
Article in Molecular systems biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Bridging Ecology and Microbiomes: Applying Ecological Theories in Host-associated Microbial Ecosystems.Current clinical microbiology reports · 2025Review
- Engineering bacterial warriors: harnessing microbes to modulate animal physiology.Current opinion in biotechnology · 2024Review
- Engineering is evolution: a perspective on design processes to engineer biology.Nature communications · 2024Article
- Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.Microbiology spectrum · 2024Article
- Sexual Dimorphic Interplays Between Gut Microbiota and Antihypertensive Drugs.Current hypertension reports · 2023Review
- Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.bioRxiv : the preprint server for biology · 2023Article
- Enhancing nutritional niche and host defenses by modifying the gut microbiome.Molecular systems biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome is essential for processing complex food compounds and synthesizing nutrients that the host cannot digest or produce, respectively. New model systems are needed to study how the metabolic capacity provided by the gut microbiome impacts the nutritional status of the host, and to explore possibilities for altering host metabolic capacity via the microbiome. Here, we colonized the nematode Caenorhabditis elegans gut with cellulolytic bacteria that enabled C. elegans to utilize cellulose, an otherwise indigestible substrate, as a carbon source. Cellulolytic bacteria as a community component in the worm gut can also support additional bacterial species with specialized roles, which we demonstrate by using Lactobacillus plantarum to protect C. elegans against Salmonella enterica infection. This work shows that engineered microbiome communities can be used to endow host organisms with novel functions, such as the ability to utilize alternate nutrient sources or to better fight pathogenic bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.