Evidence map›Paper›PMID 36377668›Full record

ArticleAngewandte Chemie (International ed. in English)2023

A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin.

Luis F Valdez Pérez, Sylvestre P J T Bachollet, Nikolai V Orlov, Kenji P M Kopf, Joseph P A Harrity

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luis F Valdez PérezDepartment of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.
Sylvestre P J T BacholletDepartment of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.
Nikolai V OrlovDepartment of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.
Kenji P M KopfDepartment of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.
Joseph P A HarrityDepartment of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.ORCID http://orcid.org/0000-0001-5038-5699

Funding

Engineering and Physical Sciences Research Council EP/S018336/1H2020 Marie Skłodowska-Curie Actions ITN-EJD 14/06-721223H2020 Marie Skłodowska-Curie Actions MCITN-2012-316379
6 · The paper itself

Abstract

We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol-mediated dynamic thermodynamic resolution process. These intermediates can be progressed to enantioenriched products through stereoretentive functionalization of the carbon-boron bond. Finally, we have exploited this method in the first highly stereoselective total synthesis of P-streptonigrin.

Indexed as

AtropisomersBoronic EstersDiastereoselectivityDynamic Thermodynamic ResolutionTotal Synthesis

Identifiers

PMID36377668
PMCPMC10107650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.