Evidence map›Paper›PMID 36377467›Full record

ArticleeLife2022

A novel cis-regulatory element drives early expression of

Jake Leyhr, Laura Waldmann, Beata Filipek-Górniok, Hanqing Zhang, Amin Allalou, Tatjana Haitina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jake Leyhr *Subdepartment of Evolution and Development, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-1815-7818
Laura Waldmann *Subdepartment of Evolution and Development, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.
Beata Filipek-GórniokScience for Life Laboratory Genome Engineering Zebrafish Facility, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.
Hanqing ZhangDivision of Visual Information and Interaction, Department of Information Technology, Uppsala University, Uppsala, Sweden.
Amin AllalouDivision of Visual Information and Interaction, Department of Information Technology, Uppsala University, Uppsala, Sweden.
Tatjana HaitinaSubdepartment of Evolution and Development, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8754-5534
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acquisition of movable jaws was a major event during vertebrate evolution. The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however knowledge about its regulatory mechanism is lacking. In this study, we report a proximal enhancer element of

Indexed as

ZebrafishAnimalsBiological EvolutionGene DeletionGene Expression Regulation, DevelopmentalGenomeHomeodomain ProteinsJawLampreysMammalsRegulatory Sequences, Nucleic AcidTranscription FactorsVertebratesZebrafish ProteinsHomeodomain Proteinsnkx3-2 protein, zebrafishTranscription FactorsZebrafish Proteinscis-regulatory elementdevelopmental biologyenhancer deletionevolutionary biologygnathostomejaw jointnkx3.2optical projection tomographyzebrafish

Identifiers

PMID36377467
PMCPMC9665848
OpenAlexW4309207471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.