Evidence map›Paper›PMID 36377091›Full record

ArticleNeuropharmacology2023

The role of adenosine in alcohol-induced respiratory suppression.

Benton S Purnell, Sydney Thompson, Tenise Bowman, Jayant Bhasin, Steven George, Brian Rust, Madhuvika Murugan, Denise Fedele, Detlev Boison

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Adenosine ANeuropharmacology · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Benton S PurnellDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Sydney ThompsonDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Tenise BowmanDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Jayant BhasinDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Steven GeorgeDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Brian RustDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA. Electronic address: bdr78@rwjms.rutgers.edu.
Madhuvika MuruganDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Denise FedeleDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Detlev BoisonDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA. Electronic address: detlev.boison@rutgers.edu.
Environmental and Occupational Health Sciences Institute · USRutgers, The State University of New Jersey · US

Funding

IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
The Role of Adenosine in Ketogenic Diet TherapyR01NS065957 · NINDS · TRINITY COLLEGE · PI BOISON, DETLEV, GEIGER, JONATHAN DAVID · 2010 to 2021
$3.9M
Therapies for Epilepsy Prevention - Focus on AdenosineR01NS127846 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Detlev Boison · 2022 to 2026
$2.1M
Adenosine receptor mediated therapies for SUDEPR01NS103740 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI BOISON, DETLEV · 2018 to 2022
$1.7M
Role of adenosinergic inhibition of serotonin neurons in seizure induced respiratory arrestF32NS117792 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI PURNELL, BENTON SCOTT · 2021 to 2024
$212k
NIGMS NIH HHS K12 GM093854NINDS NIH HHS F32 NS117792NINDS NIH HHS R01 NS065957NINDS NIH HHS R01 NS103740NINDS NIH HHS R01 NS127846
6 · The paper itself

Abstract

Alcohol-related poisoning is the foremost cause of death resulting from excessive acute alcohol consumption. Respiratory failure is crucial to the pathophysiology of fatal alcohol poisoning. Alcohol increases accumulation of extracellular adenosine. Adenosine suppresses breathing. The goal of this investigation was to test the hypothesis that adenosine signaling contributes to alcohol-induced respiratory suppression. In the first experiment, the breathing of mice was monitored following an injection of the non-selective adenosine receptor antagonist caffeine (40 mg/kg), alcohol (5 g/kg), or alcohol and caffeine combined. Caffeine reduced alcohol-induced respiratory suppression suggesting that adenosine contributes to the effects of alcohol on breathing. The second experiment utilized the same experimental design, but with the blood brain barrier impermeant non-selective adenosine receptor antagonist 8-sulfophenyltheophylline (8-SPT, 60 mg/kg) instead of caffeine. 8-SPT did not reduce alcohol-induced respiratory suppression suggesting that adenosine is contributing to alcohol-induced respiratory suppression in the central nervous system. The third and fourth experiments used the same experimental design as the first, but with the selective A

Indexed as

AdenosineRespiratory InsufficiencyAdenosine A2 Receptor AntagonistsAnimalsCaffeineEthanolMicePurinergic P1 Receptor AntagonistsReceptor, Adenosine A1Receptor, Adenosine A2ARespiratory SystemXanthinesAdenosineAdenosine A2 Receptor AntagonistsCaffeineEthanolPurinergic P1 Receptor AntagonistsReceptor, Adenosine A1Receptor, Adenosine A2AXanthinesAdenosineAlcoholBreathingCaffeineRespiratory suppression

Identifiers

PMID36377091
PMCPMC10208026
OpenAlexW4307954084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.