Evidence map›Paper›PMID 36376879›Full record

ArticleRespiratory research2022

Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS.

Vickram Tejwani, Han Woo, Chen Liu, Anna K Tillery, Amanda J Gassett, Richard E Kanner, Eric A Hoffman, Fernando J Martinez, Prescott G Woodruff, R Graham Barr and 17 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  5. Review
  6. Indoor air pollution and airway health.The Journal of allergy and clinical immunology · 2024
    Review
  7. Article
  8. Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR.American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 1 country.

Vickram TejwaniDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA. tejwanv@ccf.org.
Han WooDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Chen LiuDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Anna K TilleryCenter for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amanda J GassettDivision of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Richard E KannerDivision of Respiratory, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT, USA.
Eric A HoffmanDepartment of Radiology, Medicine and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Fernando J MartinezDivision of Pulmonology and Critical Care Medicine, Weill-Cornell Medical Center, Cornell University, New York, NY, USA.
Prescott G WoodruffDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
R Graham BarrDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Ashraf FawzyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kirsten KoehlerEnvironmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jeffrey L CurtisPulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Christine M FreemanPulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Alejandro P ComellasDivision of Pulmonary, Critical Care, and Occupational Medicine, College of Medicine, University of Iowa, Iowa City, IA, USA.
Cheryl PirozziUniversity of Utah Hospital, Salt Lake City, UT, USA.
Robert PaineUniversity of Utah Hospital, Salt Lake City, UT, USA.
Donald TashkinDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Jerry A KrishnanDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Coralynn SackDivision of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Laura M PaulinPulmonary/Critical Care, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Marina ZusmanDivision of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Joel D KaufmanDivision of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Neil E AlexisCenter for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Washington · USUniversity of California, Los Angeles · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah Hospital · USVA Ann Arbor Healthcare System · USCleveland Clinic · USColumbia University · USCornell University · USDartmouth–Hitchcock Medical Center · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Utah · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Andrea Adamcakova-Dodd · 1990 to 2026
$40.5M
University of Washington Education and Research CenterT42OH008433 · OH · UNIVERSITY OF WASHINGTON · PI SIMPSON, CHRISTOPHER D · 2005 to 2024
$29.4M
The Role of Airway Morphology in Environmental LungDiseasesK23ES030725 · NIEHS · UNIVERSITY OF WASHINGTON · PI SACK, CORALYNN SHAYNA · 2019 to 2023
$835k
Macrophage phenotype and COPD severityF32HL149258 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TEJWANI, VICKRAM · 2019 to 2020
$145k
CSRD VA I01 CX001553NHLBI NIH HHS F32 HL149258NHLBI NIH HHS F32HL149258-01NIEHS NIH HHS K23 ES030725NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES007033NIOSH CDC HHS T42 OH008433
6 · The paper itself

Abstract

backgroundAirway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, whether AM BC accurately reflects environmental PM

methodsWe analyzed induced sputum from participants at 7 of 12 sites SPIROMICS sites for AM BC content, which we related to exposures and to lung function and respiratory outcomes. Models were adjusted for batch (first vs. second), age, race (white vs. non-white), income (<$35,000, $35,000~$74,999, ≥$75,000, decline to answer), BMI, and use of long-acting beta-agonist/long-acting muscarinic antagonists, with sensitivity analysis performed with inclusion of urinary cotinine and lung function as covariates.

resultsOf 324 participants, 143 were current smokers and 201 had spirometric-confirmed COPD. Modeled indoor fine (< 2.5 μm in aerodynamic diameter) particulate matter (PM

conclusionIndoor PM

Indexed as

Air PollutantsPulmonary Disease, Chronic ObstructiveCarbonCotinineHumansMacrophagesMorbidityParticulate MatterQuality of LifeSootAir PollutantsCarbonCotinineParticulate MatterSootBlack carbonCOPDMacrophage

Identifiers

PMID36376879
PMCPMC9664618
OpenAlexW4308988625

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.