Observational studyBMC medicine2022
Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study.
Observational study in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- SARS-CoV-2 seroprevalence among pregnant women during the first three waves of the COVID-19 pandemic in southern Mozambique.BMC pregnancy and childbirth · 2026Observational
- The burden of malaria-attributable maternal anaemia and the impact of preventive treatment across sub-Saharan Africa.Nature health · 2026Article
- Over a decade of HIV infection prevalence and incidence among Mozambican pregnant women: a secondary analysis of prospectively collected data.BMC public health · 2025Article
- Malaria diagnosis challenges andPathogens and global health · 2024Article
- Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.Nature communications · 2024Article
- Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.Research square · 2023Article
- Detecting temporal and spatial malaria patterns from first antenatal care visits.Nature communications · 2023Article
- Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique.Communications biology · 2023Article
- Detecting temporal and spatial malaria patterns from first antenatal care visits.Research square · 2023Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundLow-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minimal, suggesting an immune-independent effect on parasite densities. We aimed to describe parasite densities in pregnancy, and determine how gravidity and antibody-mediated immunity affect these, during a period of declining malaria transmission in southern Mozambique.
methodsWe documented P. falciparum infections at first antenatal care visits (n = 6471) between November 2016 and October 2019 in Ilha Josina (high-to-moderate transmission area), Manhiça (low transmission area), and Magude (pre-elimination area). Two-way interactions in mixed-effects regression models were used to assess gravidity-dependent differences in quantitative PCR-determined P. falciparum positivity rates (PfPR
resultsPfPR
conclusionsThe proportion of detectable and clinically relevant infections is the highest in primigravid women from high-to-moderate transmission settings and decreases with declining malaria. In contrast, the falling malaria trends are accompanied by increased parasite densities and reduced humoral immunity among secundigravidae. Factors other than acquired immunity thus emerge as potentially important for producing less detectable infections among primigravidae during marked declines in malaria transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.