ArticleRespiratory research2022
Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD.
Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- What can we learn about bone density in COPD patients from a chest CT? A systematic review.Croatian medical journal · 2024Pooled it
- Association between muscular atrophy and mortality risk in patients with COPD: a systematic review.Therapeutic advances in respiratory diseasePooled it
- Body composition's effect on the bone-vascular axis of osteoporosis discovered in AI-based CT analysis of COPD patients.European radiology · 2026Observational
- Automated 3D chest CT muscle segmentation-derived model development and explanation in discrimination of normal, preserved ratio impaired spirometry, and COPD: a multicenter study.Insights into imaging · 2026Article
- Comparison of chest CT-derived muscle mass and body mass index in assessing disease severity and outcomes in non-cystic fibrosis bronchiectasis.BMC pulmonary medicine · 2026Article
- Coexisting Sarcopenia and Osteoporosis in COPD: Integrated Identification, Risk-Oriented Assessment, and Comprehensive Management-A Structured Narrative Review.International journal of chronic obstructive pulmonary disease · 2026Review
- Associations between sarcopenia and its developed status with chronic lung disease in the middle-aged and older Chinese people.Aging clinical and experimental research · 2025Article
- The cross-sectional area of the pectoralis major muscle and future exacerbations in patients presenting with bronchiectasis exacerbation: a prospective observational study.BMC pulmonary medicine · 2025Observational
- Quantitative CT evaluation of extrapulmonary lesions in chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2025Review
- Associations of fat, bone, and muscle indices with disease severity in patients with obstructive sleep apnea hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.International journal of chronic obstructive pulmonary disease · 2025Review
- An enhanced machine learning-based prognostic prediction model for patients with AECOPD on invasive mechanical ventilation.iScience · 2024Article
- Development and Validation of Machine Learning-Based Models for Prediction of Intensive Care Unit Admission and In-Hospital Mortality in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Diffusion-tensor magnetic resonance imaging as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia.BMC musculoskeletal disorders · 2024Article
- Is Type and Grade of Emphysema Important for Bone Mineral Density and Aortic Calcifications?Journal of clinical medicine · 2024Article
- Differentially co-expressed myofibre transcripts associated with abnormal myofibre proportion in chronic obstructive pulmonary disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Unveiling the Knowledge Frontier: A Scientometric Analysis of COPD with Sarcopenia.International journal of chronic obstructive pulmonary disease · 2024Article
- Quantitative CT screening improved lumbar BMD evaluation in older patients compared to dual-energy X-ray absorptiometry.BMC geriatrics · 2023Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a disease of accelerated aging and is associated with comorbid conditions including osteoporosis and sarcopenia. These extrapulmonary conditions are highly prevalent yet frequently underdiagnosed and overlooked by pulmonologists in COPD treatment and management. There is evidence supporting a role for bone-muscle crosstalk which may compound osteoporosis and sarcopenia risk in COPD. Chest CT is commonly utilized in COPD management, and we evaluated its utility to identify low bone mineral density (BMD) and reduced pectoralis muscle area (PMA) as surrogates for osteoporosis and sarcopenia. We then tested whether BMD and PMA were associated with morbidity and mortality in COPD.
methodsBMD and PMA were analyzed from chest CT scans of 8468 COPDGene participants with COPD and controls (smoking and non-smoking). Multivariable regression models tested the relationship of BMD and PMA with measures of function (6-min walk distance (6MWD), handgrip strength) and disease severity (percent emphysema and lung function). Multivariable Cox proportional hazards models were used to evaluate the relationship between sex-specific quartiles of BMD and/or PMA derived from non-smoking controls with all-cause mortality.
resultsCOPD subjects had significantly lower BMD and PMA compared with controls. Higher BMD and PMA were associated with increased physical function and less disease severity. Participants with the highest BMD and PMA quartiles had a significantly reduced mortality risk (36% and 46%) compared to the lowest quartiles.
conclusionsThese findings highlight the potential for CT-derived BMD and PMA to characterize osteoporosis and sarcopenia using equipment available in the pulmonary setting.
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