ArticleNature chemical biology2022
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis.
Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- TIME FOR COFFEE coordinates phase separation and chromatin regulation for salt tolerance.Science advances · 2026Article
- New perspectives on plant water sensing.Science China. Life sciences · 2026Article
- Biomolecular condensates in plant stress and development: recent advances and emerging concepts.Journal of experimental botany · 2026Review
- A practical guide to investigating biomolecular condensates: a comment from the plant community.Science China. Life sciences · 2026Review
- Opposing roles of serine and charge in IDR condensate miscibility.Nature chemical biology · 2026Article
- Redox-Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 800 million years of co-evolution in the green plant lineage: the case of LEUNIG and SEUSS transcriptional co-regulators.Molecular biology and evolution · 2026Article
- Transcriptional adapter ADA2 regulates yield and end-use quality through liquid-liquid phase separation in wheat.Journal of integrative plant biology · 2026Article
- Article
- Biomolecular Condensates in Combined and Recurrent Plant Stresses: Integrating Phase Separation, Signal Prioritization, and Cross-Stress Memory.International journal of molecular sciences · 2026Review
- Engineering Design of Artificial Phase-Separating Proteins.Biotechnology journal · 2026Review
- Prediction of plant phase-separating proteins using positive-unlabeled learning.Genome biology · 2026Article
- Liquid-liquid phase separation at the frontline of plant-pathogen battles.Plant communications · 2026Review
- From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops.International journal of molecular sciences · 2026Review
- Transcriptional outputs and condensates - formation and function.The New phytologist · 2026Review
- Review
- Phase separation in plants: mechanisms, functions, and a simplified workflow for investigation.Frontiers in plant science · 2026Review
- Phase separation and biomolecular condensate formation drive plant endomembrane and autophagy crosstalk.Journal of experimental botany · 2025Review
- Pathogen-induced condensation of the guard cell RNA-binding protein SAIR1 fine-tunes translation for immunity.Nature plants · 2025Article
- ricePSP: a database of rice phase separation-associated proteins.Genome biology · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield. However, our current knowledge on the mechanism by which plants sense osmotic stress is still limited. Here, we identify the transcriptional regulator SEUSS (SEU) as a key player in hyperosmotic stress response in Arabidopsis. SEU rapidly coalesces into liquid-like nuclear condensates when extracellular osmolarity increases. The intrinsically disordered region 1 (IDR1) of SEU is responsible for its condensation. IDR1 undergoes conformational changes to adopt more compact states after an increase in molecular crowding both in vitro and in cells, and two predicted α-helical peptides are required. SEU condensation is indispensable for osmotic stress tolerance, and loss of SEU dramatically compromises the expression of stress tolerance genes. Our work uncovers a critical role of biomolecular condensates in cellular stress perception and response and expands our understanding of the osmotic stress pathway.
Indexed as
Identifiers
36376475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.