ArticleScientific reports2022
Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Urban PMMolecular neurobiology · 2026Article
- Neurotoxic and some systemic effects of cadmium oxide nanoparticles following their subchronic intranasal administration to rats: experimental data analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Copper loading may affect rat neurobehaviour by impairing mitochondria-associated endoplasmic reticulum membranes in hippocampal neurons.Behavioral and brain functions : BBF · 2025Article
- On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles.Cardiovascular toxicology · 2024Article
- Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.MedComm · 2023Review
- Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of FeInternational journal of molecular sciences · 2023Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
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Abstract
White outbred female rats were exposed intranasally to 50-µL of suspension of lead oxide nanoparticles (PbO NPs) at a concentration of 0.5 mg/mL thrice a week during six weeks. A control group of rats was administered deionized water in similar volumes and conditions. The developed intoxication was manifested by altered biochemical and cytochemical parameters, as well as behavioral reactions of animals. Using electron microscopy and energy-dispersive X-ray spectroscopy techniques, we revealed deposition of PbO NPs in the olfactory bulb, but not in basal ganglia, and an increase in the number of axons with damage to the myelin sheath in the tissues of olfactory bulb and basal ganglia, changes in the ultrastructure of mitochondria of neurons in the tissues of olfactory bulb and basal ganglia of the brain, and differences in the mitochondrial profile of neurons in different regions of the rat brain. Our results collectively suggest that the central nervous system may be a target of low-level toxicity of lead oxide nanoparticles.
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