Evidence map›Paper›PMID 36376365›Full record

ArticleScientific reports2022

A flexible adhesive surface electrode array capable of cervical electroneurography during a sequential autonomic stress challenge.

Yifeng Bu, Jonas F Kurniawan, Jacob Prince, Andrew K L Nguyen, Brandon Ho, Nathan L J Sit, Timothy Pham, Vincent M Wu, Boris Tjhia, Andrew J Shin and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yifeng Bu *Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. ybu@ucsd.edu.
Jonas F Kurniawan *Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Jacob PrinceDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Andrew K L NguyenDepartment of Physics, University of California San Diego, La Jolla, CA, 92093, USA.
Brandon HoDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Nathan L J SitDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Timothy PhamDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Vincent M WuDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Boris TjhiaDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Andrew J ShinDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Tsung-Chin WuDivision of Biostatistics and Bioinformatics, University of California San Diego, La Jolla, CA, 92093, USA.
Xin M TuDivision of Biostatistics and Bioinformatics, University of California San Diego, La Jolla, CA, 92093, USA.
Ramesh RaoDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Todd P ColemanDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Imanuel LermanDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
University of California, San Diego · USLa Jolla Bioengineering Institute · USStanford University · US

Funding

Biomedical Advanced Research and Development Authority 75A50119C00038NIEHS NIH HHS 27302C0038
6 · The paper itself

Abstract

This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the electrode material of choice and combines it with an electrode array consisting of a customized biopotential data acquisition unit and integrated graphical user interface (GUI) for visualization of real-time monitoring. Preliminary testing demonstrated this electrode design can achieve a high signal to noise ratio during cervical neural recordings. To demonstrate the capability of the surface electrodes to detect changes in cervical neuronal activity, the cold-pressor test (CPT) and a timed respiratory challenge were employed as stressors to the autonomic nervous system. This sensor system recording, a new technique, was termed Cervical Electroneurography (CEN). By applying a custom spike sorting algorithm to the electrode measurements, neural activity was classified in two ways: (1) pre-to-post CPT, and (2) during a timed respiratory challenge. Unique to this work: (1) rostral to caudal channel position-specific (cephalad to caudal) firing patterns and (2) cross challenge biotype-specific change in average CEN firing, were observed with both CPT and the timed respiratory challenge. Future work is planned to develop an ambulatory CEN recording device that could provide immediate notification of autonomic nervous system activity changes that might indicate autonomic dysregulation in healthy subjects and clinical disease states.

Indexed as

AdhesivesNeuronsAutonomic Nervous SystemElectrodesHumansSignal-To-Noise RatioAdhesives

Identifiers

PMID36376365
PMCPMC9663551
OpenAlexW4308969618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.