Evidence map›Paper›PMID 36376329›Full record

ArticleNature communications2022

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Kensuke ShibataDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Chihiro MotozonoDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.ORCID 0000-0002-9027-742X
Masamichi NagaeDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.ORCID 0000-0002-5470-3807
Takashi ShimizuDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.
Eri IshikawaDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.
Daisuke MotookaDepartment of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.
Daisuke OkuzakiSingle Cell Genomics, Human Immunology, World Premier International Research Center Initiative Immunology Frontier Research Center, Osaka University, Suita, 565-0871, Japan.ORCID 0000-0002-4552-783X
Yoshihiro IzumiDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.ORCID 0000-0003-4608-4652
Masatomo TakahashiDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.ORCID 0000-0002-2493-2684
Nao FujimoriDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
James B WingLaboratory of Human Immunology (Single Cell Immunology), World Premier International Immunology Frontier Research Center, Osaka University, Suita, 565-0871, Japan.ORCID 0000-0002-3462-1003
Takahide HayanoDepartment of Systems Bioinformatics, Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Yoshiyuki AsaiDepartment of Systems Bioinformatics, Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Takeshi BambaDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.ORCID 0000-0002-7442-2738
Yoshihiro OgawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.ORCID 0000-0002-0834-2836
Makoto Furutani-SeikiSystems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.ORCID 0000-0002-0885-4778
Mutsunori ShiraiDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Sho YamasakiDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan. yamasaki@biken.osaka-u.ac.jp.ORCID 0000-0002-5184-6917
Kyushu University · JPThe University of Osaka · JPYamaguchi University · JPOsaka International University · JPKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MHC class I-related protein 1 (MR1) is a metabolite-presenting molecule that restricts MR1-reactive T cells including mucosal-associated invariant T (MAIT) cells. In contrast to MAIT cells, the function of other MR1-restricted T cell subsets is largely unknown. Here, we report that mice in which a T cell-specific transcription factor, B-cell lymphoma/leukemia 11B (Bcl11b), was ablated in immature thymocytes (Bcl11b

Indexed as

AutoimmunityReceptors, Antigen, T-Cell, alpha-betaAnimalsBacteriaHistocompatibility Antigens Class IMiceMinor Histocompatibility AntigensReceptors, Antigen, T-CellRepressor ProteinsTranscription FactorsTumor Suppressor ProteinsBcl11b protein, mouseHistocompatibility Antigens Class IMinor Histocompatibility AntigensMr1 protein, mouseReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaRepressor ProteinsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID36376329
PMCPMC9663695
OpenAlexW4308988641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.