ArticleNature communications2022
Cytoskeletal components can turn wall-less spherical bacteria into kinking helices.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Live imaging of bacterial actin MreBs fromBiophysics and physicobiology · 2026Article
- Cooperative and divergent properties of bacterial actin isoforms inBiophysics and physicobiology · 2026Article
- MreB: unraveling the molecular mechanisms of bacterial shape, division, and environmental adaptation.Cell communication and signaling : CCS · 2025Review
- Deciphering the impact of MreB on the morphology and pathogenicity of the aquatic pathogen Spiroplasma eriocheiris.Biology direct · 2024Article
- Integrated Information for Pathogenicity and Treatment of Spiroplasma.Current microbiology · 2024Review
- Cloning and sequencing analysis of wholeFrontiers in microbiology · 2024Article
- Assembly properties of bacterial actin MreB involved in Spiroplasma swimming motility.The Journal of biological chemistry · 2023Article
- Sequence analyses of a lipoprotein conserved with bacterial actins responsible for swimming motility of wall-less helicalmicroPublication biology · 2023Article
- Characterization of heterologously expressed Fibril, a shape and motility determining cytoskeletal protein of the helical bacteriumiScience · 2022Article
- Isolation and structure of the fibril protein, a major component of the internal ribbon forFrontiers in microbiology · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial cell shape is generally determined through an interplay between the peptidoglycan cell wall and cytoplasmic filaments made of polymerized MreB. Indeed, some bacteria (e.g., Mycoplasma) that lack both a cell wall and mreB genes consist of non-motile cells that are spherical or pleomorphic. However, other members of the same class Mollicutes (e.g., Spiroplasma, also lacking a cell wall) display a helical cell shape and kink-based motility, which is thought to rely on the presence of five MreB isoforms and a specific fibril protein. Here, we show that heterologous expression of Spiroplasma fibril and MreB proteins confers helical shape and kinking ability to Mycoplasma capricolum cells. Isoform MreB5 is sufficient to confer helicity and kink propagation to mycoplasma cells. Cryoelectron microscopy confirms the association of cytoplasmic MreB filaments with the plasma membrane, suggesting a direct effect on membrane curvature. However, in our experiments, the heterologous expression of MreBs and fibril did not result in efficient motility in culture broth, indicating that additional, unknown Spiroplasma components are required for swimming.
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