Evidence map›Paper›PMID 36376086›Full record

ArticleNeurology2022

Delirium in Adults With COVID-19-Related Acute Respiratory Distress Syndrome: Comparison With Other Etiologies.

Raphael Bernard-Valnet, Eva Favre, Adriano Bernini, Mauro Oddo, Jean-Daniel Chiche, Renaud A Du Pasquier, Andrea O Rossetti, CORO-NEURO-ICU Study Group

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Delirium and Coronavirus Disease 2019: Looking Back, Moving Forward.Critical care nursing clinics of North America · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Raphael Bernard-ValnetFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland. raphael.bernard-valnet@chuv.ch.ORCID 0000-0001-7447-344X
Eva FavreFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.
Adriano BerniniFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.
Mauro OddoFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.ORCID 0000-0002-6155-2525
Jean-Daniel ChicheFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.ORCID 0000-0002-6433-6254
Renaud A Du PasquierFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.ORCID 0000-0002-2786-3434
Andrea O RossettiFrom the Neurology Service (R.B.-V., R.A.D.P., A.O.R.), Department of Clinical Neurosciences; Department of Intensive Care Medicine (E.F., J.-D.C.); Neuroscience Critical Care Research Group (A.B.), Department of Intensive Care Medicine; and Medical Direction (M.O.), Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) and University of Lausanne, Switzerland.ORCID 0000-0002-7878-172X
CORO-NEURO-ICU Study Group
University Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesNeurologic complications have been associated with COVID-19, including delirium. Such complications have been reported to be frequent among intensive care unit (ICU)-admitted patients. We hypothesized that the rate of neurologic complications would be higher in COVID-19 associated acute respiratory distress syndrome (ARDS) than those who develop ARDS from a different cause.

methodsWe conducted a retrospective cohort study in the adult ICU of Lausanne University Hospital, including all consecutive patients fulfilling the Berlin criteria for ARDS hospitalized between December 2017 and June 2021, stratifying exposure between COVID-19 or not. The primary outcome was delirium onset during ICU stay, defined by the confusion assessment method (CAM-ICU). Exploratory outcomes included development of neurologic complications of the central nervous system (stroke, hemorrhage, and vasculitis), critical illness weakness, and 30- and 180-day all-cause mortality.

resultsThree hundred eleven patients were included in the study (253 with COVID-19 and 58 with other causes) and CAM-ICU could be assessed in 231 (74.3% in COVID-19 vs 74.1% in non-COVID-19). The proportion of patients developing delirium was similar in patients with COVID-19 and controls in univariate comparison (69.1% vs 60.5%, DISCUSSION: Compared with other etiologies, patients with COVID-19 did not have higher incidence of delirium and other neurologic complications, after accounting for underlying disease severity in patients with ARDS. Management of COVID-19-associated ARDS needed longer invasive ventilation and higher sedation, which could explain higher rates of delirium in uncontrolled studies.

Indexed as

COVID-19DeliriumRespiratory Distress SyndromeAdultCritical IllnessHumansIntensive Care UnitsRespiration, ArtificialRetrospective Studies

Identifiers

PMID36376086
PMCPMC9695422
OpenAlexW4293072713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.