Evidence map›Paper›PMID 36375840›Full record

ArticleLife science alliance2023

SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members.

Olivier Binda, Franceline Juillard, Julia Novion Ducassou, Constance Kleijwegt, Geneviève Paris, Andréanne Didillon, Faouzi Baklouti, Armelle Corpet, Yohann Couté, Jocelyn Côté and 1 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. In Search of Spinal Muscular Atrophy Disease Modifiers.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. The TUDOR domain of SMN is an H3K79Life science alliance · 2023
    Article
  10. Effectors and effects of arginine methylation.Biochemical Society transactions · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Olivier BindaUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France olivier.binda@mail.mcgill.ca patrick.lomonte@univ-lyon1.fr.ORCID 0000-0002-1539-0828
Franceline JuillardUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France.
Julia Novion DucassouUniversité Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, FR2048, Grenoble, France.
Constance KleijwegtUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France.ORCID 0000-0002-9329-0806
Geneviève ParisUniversity of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, Canada.
Andréanne DidillonUniversity of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, Canada.
Faouzi BakloutiUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France.ORCID 0000-0002-2830-292X
Armelle CorpetUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France.ORCID 0000-0002-2126-5783
Yohann CoutéUniversité Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, FR2048, Grenoble, France.ORCID 0000-0003-3896-6196
Jocelyn CôtéUniversity of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, Canada.
Patrick LomonteUniversité Claude Bernard Lyon 1, CNRS UMR 5261, INSERM U1315, LabEx DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle, Team Chromatin Dynamics, Nuclear Domains, Virus, Lyon, France olivier.binda@mail.mcgill.ca patrick.lomonte@univ-lyon1.fr.ORCID 0000-0001-9248-648X
Université Claude Bernard Lyon 1 · FRUniversity of Ottawa · CACentre National de la Recherche Scientifique · FR

Funding

CIHR MOP 123381
6 · The paper itself

Abstract

Although recent advances in gene therapy provide hope for spinal muscular atrophy (SMA) patients, the pathology remains the leading genetic cause of infant mortality. SMA is a monogenic pathology that originates from the loss of the

Indexed as

Fragile X Messenger Ribonucleoprotein 1Muscular Atrophy, SpinalSurvival of Motor Neuron 1 ProteinHumansInfantMotor NeuronsProteomicsRNAFragile X Messenger Ribonucleoprotein 1RNASMN1 protein, humanSurvival of Motor Neuron 1 Protein

Identifiers

PMID36375840
PMCPMC9684302
OpenAlexW4308997596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.