Evidence map›Paper›PMID 36375838›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2023

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.

Andrea J White, Sonia M Parnell, Adam Handel, Stefano Maio, Andrea Bacon, Emilie J Cosway, Beth Lucas, Kieran D James, Jennifer E Cowan, William E Jenkinson and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Generation and repair of thymic epithelial cells.The Journal of experimental medicine · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Andrea J WhiteInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-6950-6729
Sonia M ParnellInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-4430-9072
Adam HandelDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, United Kingdom.
Stefano MaioDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9518-6466
Andrea BaconInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-2688-8952
Emilie J CoswayInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Beth LucasInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Kieran D JamesInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Jennifer E CowanDivision of Infection and Immunity, University College London, London, United Kingdom.
William E JenkinsonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-3422-8372
Georg A HollanderDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-8790-0874
Graham AndersonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; g.anderson@bham.ac.uk.ORCID 0000-0002-2917-4085
NIHR Birmingham Biomedical Research Centre · GBUniversity of Oxford · GBInstitute of Infection and Immunity · CAUniversity of Basel · CH

Funding

Medical Research Council MR/T029765/1Wellcome Trust 211944
6 · The paper itself

Abstract

In the thymus, cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells support αβT cell development from lymphoid progenitors. For cTECs, expression of a specialized gene signature that includes

Identifiers

PMID36375838
PMCPMC9772400
OpenAlexW4309093952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.