Evidence map›Paper›PMID 36375644›Full record

ArticleMetabolism: clinical and experimental2023

Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts.

Malgorzata E Rogalska, Elizabeth Vafiadaki, Zoi Erpapazoglou, Kobra Haghighi, Lisa Green, Christos S Mantzoros, Roger J Hajjar, Michael Tranter, Ioannis Karakikes, Evangelia G Kranias and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Genetic landscape of phospholamban cardiomyopathies.Frontiers in cell and developmental biology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Malgorzata E RogalskaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
Elizabeth VafiadakiMolecular Biology Division, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Zoi ErpapazoglouInstitute for Fundamental Biomedical Research, B.S.R.C. "Alexander Fleming", 16672 Athens, Greece.
Kobra HaghighiDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lisa GreenDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Christos S MantzorosDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA 02215, USA.
Roger J HajjarFlagship Pioneering, Cambridge, MA 02142, USA.
Michael TranterDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Ioannis KarakikesDepartment of Cardiothoracic Surgery and Cardiovascular Institute, Stanford University School of Medicine, 240 Pasteur Dr, Stanford, CA 94304, USA.
Evangelia G KraniasDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Francesca StillitanoDivision Heart and Lung, Department of Cardiology, University Medical Center Utrecht, 3584, CX, Utrecht, the Netherlands.
Panagiota KafaslaInstitute for Fundamental Biomedical Research, B.S.R.C. "Alexander Fleming", 16672 Athens, Greece.
Despina SanoudouMolecular Biology Division, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece; Clinical Genomics and Pharmacogenomics Unit, 4(th) Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: dsanoudou@med.uoa.gr.
University of Cincinnati Medical Center · USBiomedical Research Foundation of the Academy of Athens · GRCentre for Genomic Regulation · ESFlagship Pioneering (United States) · US

Funding

Unraveling the pathogenesis of familial dilated cardiomyopathy towards precision medicineR01HL139679 · NHLBI · STANFORD UNIVERSITY · PI Ioannis Karakikes · 2018 to 2026
$4.2M
The Role of 3-Dimensional Genome Integrity In Cardiac LaminopathiesR01HL150414 · NHLBI · STANFORD UNIVERSITY · PI KARAKIKES, IOANNIS · 2020 to 2023
$2.1M
NHLBI NIH HHS R01 HL139679NHLBI NIH HHS R01 HL150414
6 · The paper itself

Abstract

Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in the phospholamban (PLN) gene has been implicated in the pathogenesis of ACM. PLN is a key regulator of sarcoplasmic reticulum (SR) Ca

Indexed as

Action PotentialsCalcium-Binding ProteinsInduced Pluripotent Stem CellsMyocytes, CardiacAnimalsCalciumHeartHumansMiceNerve Tissue ProteinsPhospholambanProtein IsoformsCalciumCalcium-Binding ProteinsNerve Tissue ProteinsPhospholambanProtein IsoformsSRRM4 protein, humanAlternative splicingArrhythmiaCardiomyopathyGenomicsMicroexons

Identifiers

PMID36375644
PMCPMC12758590
OpenAlexW4308924425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.