Evidence map›Paper›PMID 36374992›Full record

ArticleMolecular pharmaceutics2022

Dual-Responsive Glycopolymers for Intracellular Codelivery of Antigen and Lipophilic Adjuvants.

Judith De Mel, Mehjabeen Hossain, Oluwaseyi Shofolawe-Bakare, Sk Arif Mohammad, Emily Rasmussen, Khadeeja Milloy, Micaela Shields, Eric W Roth, Karan Arora, Rafael Cueto and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Application of nanomedicines in tumor immunotherapy.Journal of molecular cell biology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Judith De MelDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.
Mehjabeen HossainDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.
Oluwaseyi Shofolawe-BakareDepartment of Chemical Engineering, University of Mississippi, University, Mississippi 38677, United States.
Sk Arif MohammadDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.
Emily RasmussenDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi 38677, United States.
Khadeeja MilloyDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.
Micaela ShieldsDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.
Eric W RothNorthwestern University Atomic and Nanoscale Characterization Experimental Center, Evanston, Illinois, 60208, United States.
Karan AroraDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
Rafael CuetoDepartment of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Shou-Ching TangCancer Center and Research Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, United States.
John T WilsonDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-9144-2634
Adam E SmithDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0003-1733-443X
Thomas A WerfelDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi 38677, United States.ORCID 0000-0002-6005-1243
University of Mississippi · USUniversity of Mississippi Medical Center · USVanderbilt University · USLouisiana State University · USNorthwestern University · US

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Traditional approaches to vaccines use whole organisms to trigger an immune response, but they do not typically generate robust cellular-mediated immunity and have various safety risks. Subunit vaccines composed of proteins and/or peptides represent an attractive and safe alternative to whole organism vaccines, but they are poorly immunogenic. Though there are biological reasons for the poor immunogenicity of proteins and peptides, one other key to their relative lack of immunogenicity could be attributed to the poor pharmacokinetic properties of exogenously delivered proteins and peptides. For instance, peptides often aggregate at the site of injection and are not stable in biological fluids, proteins and peptides are rapidly cleared from circulation, and both have poor cellular internalization and endosomal escape. Herein, we developed a delivery system to address the lack of protein immunogenicity by overcoming delivery barriers as well as codelivering immune-stimulating adjuvants. The glycopolymeric nanoparticles (glycoNPs) are composed of a dual-stimuli-responsive block glycopolymer, poly[2-(diisopropylamino)ethyl methacrylate]-

Indexed as

AntigensNanoparticlesAdjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsDendritic CellsMethacrylatesMiceMice, Inbred C57BLOvalbuminVaccines, SubunitAdjuvants, ImmunologicAdjuvants, PharmaceuticAntigensMethacrylatesOvalbuminVaccines, Subunitglycopolymerimmunotherapynanovaccinestimuli responsivenesssubunit vaccine

Identifiers

PMID36374992
PMCPMC10013197
OpenAlexW4308964746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.