Evidence map›Paper›PMID 36374968›Full record

ArticleCirculation2022

Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction.

Sui Zhang, Shijie Liu, John P Leach, Ke Li, Emerson C Perin, James F Martin

Open access · bronzeAbstract readLetter
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Past, Present and Future of Regenerative Gene Therapy for Ischemic Heart Failure.Journal of cardiovascular translational research · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Control of stem cell renewal and fate by YAP and TAZ.Nature reviews. Molecular cell biology · 2023
    Review
  9. Cellular reprogramming of fibroblasts in heart regeneration.Journal of molecular and cellular cardiology · 2023
    Review
  10. Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.Journal of molecular and cellular cardiology · 2023
    Review
  11. Hippo Signaling: Advances in Potential Therapeutic Targets for Sinoatrial Node Disorders.International journal of drug discovery and pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sui Zhang *Texas Heart Institute, Houston (S.L., S.Z., K.L., E.C.P., J.F.M.).ORCID 0000-0002-2351-1300
Shijie Liu *Texas Heart Institute, Houston (S.L., S.Z., K.L., E.C.P., J.F.M.).ORCID 0000-0002-2597-5416
John P Leach *Baylor College of Medicine, Houston, TX. Yap Therapeutics Inc., Houston, TX (J.P.L.).
Ke LiTexas Heart Institute, Houston (S.L., S.Z., K.L., E.C.P., J.F.M.).
Emerson C PerinTexas Heart Institute, Houston (S.L., S.Z., K.L., E.C.P., J.F.M.).
James F MartinTexas Heart Institute, Houston (S.L., S.Z., K.L., E.C.P., J.F.M.).ORCID 0000-0002-7842-9857
Houston Methodist · USBaylor College of Medicine · US

Funding

Pitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1M
Hippo and Wnt Signaling in Cardiac RegenerationR01HL127717 · NHLBI · TEXAS HEART INSTITUTE · PI MARTIN, JAMES F · 2016 to 2023
$4.4M
Optical elastography for assessment of myocardial regenerationR01HL130804 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARIN, KIRILL V, MARTIN, JAMES F · 2016 to 2019
$2.9M
NHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL127717NHLBI NIH HHS R01 HL130804
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hippo Signaling PathwayMyocardial InfarctionAnimalsArrhythmias, CardiacGenetic TherapySwinearrhythmiasgenetic therapyHippo signaling pathwaymyocardial infarction

Identifiers

PMID36374968
PMCPMC9680005
OpenAlexW4308992069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.