Evidence map›Paper›PMID 36374965›Full record

ArticleThe CRISPR journal2022

CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito,

Guan-Heng Zhu, Sharath Chandra Gaddelapati, Yaoyu Jiao, Jinmo Koo, Subba Reddy Palli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The CRISPR journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guan-Heng ZhuDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-4544-4903
Sharath Chandra GaddelapatiDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Yaoyu JiaoDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Jinmo KooDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Subba Reddy PalliDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-0873-3247
University of Kentucky · US

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
Molecular mode of action of Juvenile hormone analogsR21AI163561 · NIAID · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2021 to 2022
$399k
NIAID NIH HHS R21 AI163561NIGMS NIH HHS R01 GM070559
6 · The paper itself

Abstract

Methoprene, a juvenile hormone (JH) analog, is widely used for insect control, but its mode of action is not known. To study methoprene action in the yellow fever mosquito,

Indexed as

AedesYellow FeverAnimalsCRISPR-Cas SystemsGene EditingInsect ProteinsJuvenile HormonesLarvaMetamorphosis, BiologicalMethoprenePupaTranscription FactorsInsect ProteinsJuvenile HormonesMethopreneTranscription Factors

Identifiers

PMID36374965
PMCPMC9805843
OpenAlexW4308993472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.