Evidence map›Paper›PMID 36374769›Full record

Trial reportEBioMedicine2022

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial.

Lucas Jurado-Fasoli, Xinyu Di, Guillermo Sanchez-Delgado, Wei Yang, Francisco J Osuna-Prieto, Lourdes Ortiz-Alvarez, Elke Krekels, Amy C Harms, Thomas Hankemeier, Milena Schönke and 6 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02365129 (Activating Brown Adipose Tissue Through Exercise), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02365129 naunknown statusnot on this map

Activating Brown Adipose Tissue Through Exercise: Randomized Controlled Trial

TypeinterventionalSponsorUniversidad de GranadaRan2015 to 2017Enrolled180ConditionsObesity, Diabetes Mellitus, Metabolic Syndrome XArmsExercise training based on recommendations for adults (WHO)
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  20. Adrenic acid: A promising biomarker and therapeutic target (Review).International journal of molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Lucas Jurado-FasoliPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
Xinyu DiDepartment of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.
Guillermo Sanchez-DelgadoPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Wei YangDepartment of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.
Francisco J Osuna-PrietoPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Department of Analytical Chemistry, University of Granada, Granada, Spain; Research and Development of Functional Food Centre (CIDAF), Granada, Spain.
Lourdes Ortiz-AlvarezPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain.
Elke KrekelsDepartment of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.
Amy C HarmsDepartment of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.
Thomas HankemeierDepartment of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.
Milena SchönkeDepartment of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Concepcion M AguileraDepartment of Biochemistry and Molecular Biology II, ..úJos.. Mataix Verd....Ñ Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada 18016, Spain; Instituto de Investigaci..n Biosanitaria, ibs.Granada, Granada, Spain; CIBER Fisiopatolog.ía de la Obesidad y la Nutrici..n (CIBEROBN), Madrid 28029, Spain.
Jose M Llamas-ElviraInstituto de Investigaci..n Biosanitaria, ibs.Granada, Granada, Spain; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Isabelle KohlerDivision of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam, the Netherlands; Center for Analytical Sciences Amsterdam, Amsterdam, the Netherlands.
Patrick C N RensenDepartment of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Jonatan R RuizPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Instituto de Investigaci..n Biosanitaria, ibs.Granada, Granada, Spain. Electronic address: ruizj@ugr.es.
Borja Martinez-TellezPROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands; Department of Education, Faculty of Education Sciences and SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almer.ía, Almer.ía, Spain. Electronic address: borjammt@ual.es.
Universidad de Granada · ESLeiden University · NLLeiden University Medical Center · NLInstituto de Investigación Biosanitaria de Granada · ESPennington Biomedical Research Center · USVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatty acid-derived lipid mediators including oxylipins, endocannabinoids (eCBs), and their analogues, have emerged as key metabolites in the inflammatory and immune response to physiological stressors.

methodsThis report was based on a sub-study and secondary analyses the ACTIBATE single-center unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129). The study was performed in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada. Eligible participants were young, sedentary adults with no chronic diseases. Here, we performed both an acute endurance and resistance exercise sub-studies (n.ß=.ß14 and 17 respectively), and a 24-week supervised exercise intervention, combining endurance and resistance exercise training at moderate-intensity (MOD-EX) or vigorous-intensity (VIG-EX) exercise groups, in young sedentary adults. Randomization was performed by unrestricted randomization. Plasma levels of oxylipins, eCBs, and their analogues were measured using liquid chromatography-tandem mass spectrometry.

findingsBoth endurance and resistance exercise increased by.ß+50% the plasma levels of dihomo-..-linolenic acid and arachidonic acid (AA) omega-6 derived oxylipins, as well as eicosapentaenoic acid and docosahexaenoic acid omega-3 derived after 3 and 120.ßmin of the bout of exercise (all ..

interpretationEndurance and resistance exercises acutely increased plasma levels of oxylipins, eCBs, and their analogues, whereas 24 weeks of exercise training decreased fasting plasma levels of omega-6 oxylipins, and eCBs analogues in young, sedentary adults.

fundingSee Acknowledgments section.

Indexed as

EndocannabinoidsOxylipinsAdultDocosahexaenoic AcidsEicosapentaenoic AcidExerciseHumansDocosahexaenoic AcidsEicosapentaenoic AcidEndocannabinoidsOxylipinsAerobicBioactive lipidsConcurrent trainingInflammation resolutionStrength

Identifiers

PMID36374769
PMCPMC9626892
OpenAlexW4307435157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.