Evidence map›Paper›PMID 36374451›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.

Alejandra V Contreras, David L Wiest

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alejandra V ContrerasBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
David L WiestBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA. david.wiest@fccc.edu.
Fox Chase Cancer Center · US

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI Maria Ciofani · 2014 to 2026
$26.3M
NIAID NIH HHS P01 AI102853
6 · The paper itself

Abstract

While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

Indexed as

Military PersonnelReceptors, Antigen, T-Cell, gamma-deltaCell DifferentiationCell LineageHumansReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaDevelopmentEffector fateLigandThymusγδ T cells

Identifiers

PMID36374451
OpenAlexW4309013959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.