Evidence map›Paper›PMID 36374410›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Remote Ischemic Pre-Conditioning (RIPC).

Kyung Eun Lee, Jongsoo Kim, Ki Ho Park, Jianjie Ma, Hua Zhu

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kyung Eun LeeDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jongsoo KimDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ki Ho ParkDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jianjie MaDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Hua ZhuDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Hua.Zhu@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's diseaseR01AG072430 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma · 2022 to 2026
$3.4M
MG53 function in muscle agingR01AG071676 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma, Ki Ho Park · 2022 to 2026
$3.1M
Regulation of Mitsugumin 29 expression in muscle physiology and diseasesR01AR067766 · NIAMS · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2016 to 2020
$1.6M
Inhibiting Cell Death for Protecting Cardiac InjuryR01HL153876 · NHLBI · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL153876NIAMS NIH HHS R01 AR067766NIA NIH HHS R01 AG071676NIA NIH HHS R01 AG072430
6 · The paper itself

Abstract

Ischemic pre-conditioning has been shown to protect hearts against ischemia/reperfusion (I/R)-induced cardiac injury. However, it is not feasible in clinic. Many researchers have tried to introduce brief I/R in skeletal muscle to mimic cardiac ischemic pre-conditioning, called remote ischemia pre-conditioning (RIPC). Studies from our group and other groups have shown that RIPC induces the release of cytokines from skeletal muscle (myokines) for tissue protection. Myokines play a central role in repair, inflammatory, and immune responses after injury. Thus, the detailed protocol for RIPC might be useful for researchers to study mechanisms underlying RIPC-mediated tissue protection and crosstalk. Here, we describe a detailed RIPC protocol and show MG53 secretion after RIPC into the blood.

Indexed as

Ischemic PreconditioningReperfusion InjuryCytokinesHumansIschemiaMuscle, SkeletalCytokinesMG53MyokineRemote ischemia pre-conditioning (RIPC)Tissue crosstalk

Identifiers

PMID36374410
PMCPMC11168468
OpenAlexW4308970536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.