Evidence map›Paper›PMID 36374101›Full record

ArticleInfection and immunity2022

IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections.

Jessica I Gann, Priyangi A Malaviarachchi, Wuying Du, Miguel A B Mercado, Lin-Xi Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Cytotoxic CD4+ T Cells Are Induced during Infection with Chlamydia trachomatis.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jessica I GannDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Priyangi A MalaviarachchiDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Wuying DuDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Miguel A B MercadoDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.
Lin-Xi LiDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.ORCID 0000-0002-5526-8966
University of Arkansas for Medical Sciences · US

Funding

Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Mechanisms of memory CD4 T cell-mediated immune protection against ChlamydiaR01AI139124 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI LI, LIN-XI · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI139124NIGMS NIH HHS P20 GM103625
6 · The paper itself

Abstract

CD4 T cell-dependent IFNγ production and antibody are the two best known effectors for protective immunity against Chlamydia female reproductive tract (FRT) infection. Nevertheless, mice lacking either IFNγ or B cells can clear the vast majority of Chlamydia from the FRT, while suffering from varying degrees of disseminated infection. In this study, we investigated whether IFNγ and B cells play complementary roles in host defense against Chlamydia and evaluated their relative contributions in systemic and mucosal tissues. Using mice deficient in both IFNγ and B cells (IFNγ

Indexed as

Chlamydia InfectionsChlamydia muridarumReproductive Tract InfectionsAnimalsAntibodies, BacterialChlamydia trachomatisFemaleInterferon-gammaMiceReinfectionAntibodies, BacterialInterferon-gammaantibodyChlamydiadisseminationIFNγinfectionreinfection

Identifiers

PMID36374101
PMCPMC9753678
OpenAlexW4308968501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.