Evidence map›Paper›PMID 36374100›Full record

ArticleInfection and immunity2022

Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner.

Andrew S Wagner, Amanda K Vogel, Stephen W Lumsdaine, Elise K Phillips, Hubertine M E Willems, Brian M Peters, Todd B Reynolds

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Loss of Fgr41 inInfection and immunity · 2026
    Article
  2. Disruption tomSphere · 2024
    Article
  3. Article
  4. Impact of secreted glucanases upon the cell surface and fitness ofCell surface (Amsterdam, Netherlands) · 2024
    Article
  5. Article
  6. Article
  7. The Interplay betweenMicroorganisms · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew S WagnerDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Amanda K VogelIntegrated Program in Biomedical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Centergrid.267301.1, Memphis, Tennessee, USA.
Stephen W LumsdaineDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Elise K PhillipsDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-3361-7475
Hubertine M E WillemsDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Centergrid.267301.1, Memphis, Tennessee, USA.
Brian M PetersDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Centergrid.267301.1, Memphis, Tennessee, USA.ORCID 0000-0002-0445-2077
Todd B ReynoldsDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-2867-7182
University of Tennessee at Knoxville · USUniversity of Tennessee Health Science Center · US

Funding

Candidalysin: a key mediator of Candida vaginitis immunopathologyR01AI134796 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Brian M Peters · 2018 to 2026
$2.9M
Regulation of ß(1,3)-glucan exposure in Candida albicansR01AI153599 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI REYNOLDS, TODD B · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI134796NIAID NIH HHS R01 AI153599
6 · The paper itself

Abstract

Shielding the immunogenic cell wall epitope β(1, 3)-glucan under an outer layer of mannosylated glycoproteins is an essential virulence factor deployed by Candida albicans during systemic infection. Accordingly, mutants with increased β(1, 3)-glucan exposure (unmasking) display increased immunostimulatory capabilities

Indexed as

CandidiasisCandidiasis, OralCandidiasis, VulvovaginalAnimalsCandida albicansDisease ProgressionFemaleGlucansMaleMiceGlucans3)-glucanCandidamucosaloropharyngealvirulencevulvovaginalβ(1

Identifiers

PMID36374100
PMCPMC9753624
OpenAlexW4308952345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.