Evidence map›Paper›PMID 36374090›Full record

ArticlemBio2022

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic

Robeena Farzand, Richard D Haigh, Philip Monk, Pranabashis Haldar, Hemu Patel, Manish Pareek, Raman Verma, Michael R Barer, Gerrit Woltmann, Lauren Ahyow and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Robeena Farzand *Leicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Richard D Haigh *Leicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Philip MonkPublic Health England, Department of Health and Social Care in England, Government Agency, East Midlands, UK.
Pranabashis HaldarLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Hemu PatelLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Manish PareekLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Raman VermaLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Michael R BarerLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Gerrit WoltmannLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Lauren AhyowNational TB Unit, UK Health Security Agency, Government Agency, London, UK.
Heena JagatiaLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Jonathan DeckerLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Galina V MukamolovaLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.ORCID 0000-0001-5697-2018
Andrea M CooperLeicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Natalie J Garton *Leicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.
Helen M O'Hare *Leicester TB Research Group, Department of Respiratory Sciences, University of Leicestergrid.9918.9, Leicester, UK.ORCID 0000-0002-8666-7433
University of Leicester · GBPublic Health England · GBUK Health Security Agency · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K000330/1Biotechnology and Biological Sciences Research Council BB/P001513/1Medical Research Council G0300403Medical Research Council MR/P011136/1Medical Research Council MR/P023061/1
6 · The paper itself

Abstract

The genetic diversity of Mycobacterium tuberculosis can influence disease severity and transmissibility. To better understand how this diversity influences individuals and communities, we phenotyped M. tuberculosis that was causing a persistent outbreak in the East Midlands, United Kingdom. Compared to nonoutbreak isolates, bacilli had higher lipid contents and more hydrophobic cell surfaces. In macrophage infection models, the bacteria increased more rapidly, provoked the enhanced accumulation of macrophage lipid droplets and enhanced the secretion of IL-1β. Natural deletions in

Indexed as

Mycobacterium tuberculosisTuberculosisBacterial ProteinsDisease OutbreaksHumansMacrophagesPhenotypeUnited KingdomBacterial Proteinsgenomeslung infectionmolecular epidemiologyMycobacterium tuberculosistuberculosis

Identifiers

PMID36374090
PMCPMC9765663
OpenAlexW4308953198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.