Evidence map›Paper›PMID 36374038›Full record

ArticlemBio2022

Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus.

Christine Hehnly, Aiqin Shi, Paddy Ssentongo, Lijun Zhang, Albert Isaacs, Sarah U Morton, Nicholas Streck, Petra Erdmann-Gilmore, Igor Tolstoy, R Reid Townsend and 6 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Journal of bacteriology · 2026
    Article
  2. Observational
  3. Review
  4. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Christine HehnlyInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Aiqin ShiInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Paddy SsentongoDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Lijun ZhangDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Albert IsaacsDivision of Neurosurgery, Department of Clinical Neuroscience, University of Calgarygrid.22072.35, Calgary, Alberta, Canada.
Sarah U MortonDivision of Newborn Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Nicholas StreckDepartment of Pathology and Laboratory Medicine Division of Clinical Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Petra Erdmann-GilmoreDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Igor TolstoyNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
R Reid TownsendDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
David D LimbrickDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Joseph N PaulsonInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Jessica E EricsonDivision of Pediatric Infectious Disease, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Michael Y GalperinNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-2265-5572
Steven J SchiffDepartment of Neurosurgery, Yale University, New Haven, Connecticut, USA.
James R BroachInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-1197-0312
Pennsylvania State University · USNational Institutes of Health · USWashington University in St. Louis · USBoston Children's Hospital · USCase Western Reserve University · USNeurological Surgery · USUniversity of Calgary · CAYale University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious DiseaseR01AI145057 · NIAID · YALE UNIVERSITY · PI SCHIFF, STEVEN J · 2018 to 2022
$8.1M
Control of the Neonatal Septisome and Hydrocephalus in sub-Saharan AfricaDP1HD086071 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCHIFF, STEVEN J · 2015 to 2019
$4.1M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
NCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI145057NICHD NIH HHS DP1 HD086071NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hydrocephalus in these areas. Since many children with hydrocephalus suffer poor long-term outcomes despite surgical intervention, prevention of hydrocephalus remains paramount. Our previous studies implicated a novel bacterial pathogen, Paenibacillus thiaminolyticus, as a causal agent of neonatal sepsis and postinfectious hydrocephalus in Uganda. Here, we report the isolation of three

Indexed as

ProteomicsVirulence FactorsAnimalsFimbriae, BacterialMicePaenibacillusUgandaVirulence FactorsPaenibacillus thiaminolyticuspostinfectious hydrocephalustype IV pilusvirulence factors

Identifiers

PMID36374038
PMCPMC9765702
OpenAlexW4308957943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.