Evidence map›Paper›PMID 36374023›Full record

ArticleAntimicrobial agents and chemotherapy2022

Pharmacokinetic-Pharmacodynamic Target Attainment Analyses as Support for Meropenem-Vaborbactam Dosing Regimens and Susceptibility Breakpoints.

S M Bhavnani, M Trang, D C Griffith, O Lomovskaya, J P Hammel, J S Loutit, S K Cammarata, M N Dudley, P G Ambrose, C M Rubino

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Mutations inJAC-antimicrobial resistance · 2023
    Article
  13. Novel Antimicrobial Agents for Gram-Negative Pathogens.Antibiotics (Basel, Switzerland) · 2023
    Review
  14. Impact ofJAC-antimicrobial resistance · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

S M BhavnaniInstitute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.ORCID 0000-0003-4891-6467
M TrangInstitute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.ORCID 0000-0002-3468-3343
D C GriffithRempex Pharmaceuticals, San Diego, California, USA.ORCID 0000-0002-2922-3852
O LomovskayaRempex Pharmaceuticals, San Diego, California, USA.ORCID 0000-0001-8637-3139
J P HammelInstitute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.
J S LoutitRempex Pharmaceuticals, San Diego, California, USA.
S K CammarataMelinta Therapeutics, Inc., Lincolnshire, Illinois, USA.
M N DudleyRempex Pharmaceuticals, San Diego, California, USA.
P G AmbroseInstitute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.ORCID 0000-0002-2230-1125
C M RubinoInstitute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.ORCID 0000-0003-3172-0847
Institute for Clinical Pharmacodynamics (United States) · USMelinta Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meropenem-vaborbactam is a fixed-dose beta-lactam/beta-lactamase inhibitor with potent

Indexed as

Anti-Bacterial AgentsUrinary Tract InfectionsAdministration, Intravenousbeta-Lactamase InhibitorsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial Agentsbeta-Lactamase Inhibitorsdose selectionmeropenem-vaborbactampharmacokinetic-pharmacodynamic target attainmentsusceptibility breakpoints

Identifiers

PMID36374023
PMCPMC9764998
OpenAlexW4308959327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.