Trial reportAnnals of neurology2023
Plasma Metabolites Link Dietary Patterns to Stroke Risk.
Trial report in Annals of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Workplace food purchases, dietary intake, and gut microbial metabolites in a secondary analysis of the ChooseWell 365 study.The American journal of clinical nutrition · 2024Trial
- A metabolite index of ultra-processed food intake is associated with stroke, cancer mortality, and all-cause mortality.medRxiv : the preprint server for health sciences · 2026Article
- Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS.Translational stroke research · 2025Article
- Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Scientific data · 2025Article
- The effect of L-carnitine supplementation on anthropometric and malnutrition status in acute ischemic stroke patients: a triple-blinded randomized clinical trial.BMC nutrition · 2025Article
- The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke.Frontiers in pharmacology · 2025Review
- The Interplay of Diet, Genome, Metabolome, and Gut Microbiome in Cardiovascular Disease: A Narrative Review.Current medicinal chemistry · 2025Review
- Towards the prediction of drug solubility in binary solvent mixtures at various temperatures using machine learning.Journal of cheminformatics · 2024Article
- Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.Translational stroke research · 2024Observational
- The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and Metabolites in Chronic Kidney Disease.Nutrients · 2024Article
- Systematic Insights into the Relationship between the Microbiota-Gut-Brain Axis and Stroke with the Focus on Tryptophan Metabolism.Metabolites · 2024Review
- Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes.Neurology · 2024Observational
- Plasma Metabolites and Life's Simple 7 in REGARDS.Stroke · 2024Article
- Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke.Theranostics · 2024Article
- Plant Protein but Not Animal Protein Consumption Is Associated with Frailty through Plasma Metabolites.Nutrients · 2023Article
- Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.JAMA network open · 2023Observational
- Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association of Circulating Metabolites With Racial Disparities in Hypertension and Stroke in the REGARDS Study.Neurology · 2023Article
- Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
objectiveWhile dietary intake is linked to stroke risk, surrogate markers that could inform personalized dietary interventions are lacking. We identified metabolites associated with diet patterns and incident stroke in a nested cohort from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
methodsLevels of 162 metabolites were measured in baseline plasma from stroke cases (n = 1,198) and random controls (n = 904). We examined associations between metabolites and a plant-based diet pattern previously linked to reduced stroke risk in REGARDS. Secondary analyses included 3 additional stroke-associated diet patterns: a Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Southern diet. Metabolites were tested using Cox proportional hazards models with incident stroke as the outcome. Replication was performed in the Jackson Heart Study (JHS). Inverse odds ratio-weighted mediation was used to determine whether metabolites mediated the association between a plant-based diet and stroke risk.
resultsMetabolites associated with a plant-based diet included the gut metabolite indole-3-propionic acid (β = 0.23, 95% confidence interval [CI] [0.14, 0.33], p = 1.14 × 10
interpretationA subset of diet-related metabolites are associated with risk of stroke. These metabolites could serve as surrogate markers that inform dietary interventions. ANN NEUROL 2023;93:500-510.
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