ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2023
Subjective Cognitive Decline Is Associated With Lower Baseline Cognition and Increased Rate of Cognitive Decline.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Subjective cognitive decline and objective cognitive performance in older adults: A systematic review of longitudinal and cross-sectional studies.Journal of neuropsychology · 2025Pooled it
- Age and sex differences in cognitive performance in people with subjective cognitive decline and associated worry: Findings from the Canadian Longitudinal Study on Aging.Journal of neuropsychology · 2026Article
- Sex differentiated and domain specific patterns of longitudinal cognitive decline across subjective cognitive decline and amyloid positivity groups.medRxiv : the preprint server for health sciences · 2026Article
- Do white matter hyperintensities account for the relationship between discrimination and memory?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Do Perspectives Matter? Comparing Patient, Informant, and Clinician Subjective Cognitive Decline.medRxiv : the preprint server for health sciences · 2026Article
- Self-Reported Insomnia and Poor Sleep Quality Are Associated with Self-Reported Cognitive Changes in Older Adults.Clocks & sleep · 2025Article
- Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults.Journal of the American Heart Association · 2025Article
- Cognitive Performance Among Older Adults with Subjective Cognitive Decline.Geriatrics (Basel, Switzerland) · 2025Article
- The mobile everyday cognition scale (mECog): Development and pilot testing.The Clinical neuropsychologist · 2025Article
- Rethinking neuropsychological test validity in dementia assessment: a critical review in the age of neuroimaging and digital markers.Frontiers in human neuroscience · 2025Review
- Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults.Neurobiology of aging · 2024Article
- Differentiation between Normal Cognition and Subjective Cognitive Decline in Older Adults Using Discrepancy Scores Derived from Neuropsychological Tests.Geriatrics (Basel, Switzerland) · 2024Article
- Subjective Cognitive Impairment Can Be Detected from the Decline of Complex Cognition: Findings from the Examination of Remedes 4 Alzheimer's (R4Alz) Structural Validity.Brain sciences · 2024Article
- Genetic Risk for Alzheimer's Disease Alters Perceived Executive Dysfunction in Cognitively Healthy Middle-Aged and Older Adults.Journal of Alzheimer's disease reports · 2024Article
- Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline.Neurology · 2023Observational
- Using digital assessment technology to detect neuropsychological problems in primary care settings.Frontiers in psychology · 2023Article
- Subjective cognitive decline is a better marker for future cognitive decline in females than in males.Alzheimer's research & therapy · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesSubjective cognitive decline (SCD) is a known risk factor for Alzheimer's disease. However, little research has examined whether healthy older adults with SCD (SCD+) exhibit lower cognition and increased rates of cognitive decline compared to those without SCD (SCD-). The goal of this study was to examine if cognitive change over a 15-year period differs between SCD+ and SCD-.
method3,019 cognitively normal older adults (831 SCD+) from 3 Rush Alzheimer's Disease Center cohort studies were followed annually for up to a maximum of 15 years. Due to attrition, the average follow-up time was 5.7 years. Cognition was measured using z-scores of global cognition, episodic memory, semantic memory, perceptual speed, visuospatial ability, and working memory. Linear mixed-effects models investigated whether SCD was associated with cognitive change.
resultsBoth baseline cognition and cognitive change over time differed between SCD+ and SCD-. People with SCD+ exhibited lower baseline scores and a steeper decline in global cognition, episodic memory, semantic memory, and perceptual speed. People with SCD+ did not differ from SCD- in baseline visuospatial ability or working memory but exhibited increased change over time in those two domains compared to SCD-. DISCUSSION: The observed results reveal that older adults with SCD+ have lower baseline cognition and steeper declines in cognition over time compared to SCD-. Older adults with SCD may be aware of subtle cognitive declines that occur over time in global cognition, episodic memory, semantic memory, perceptual speed, visuospatial ability, and working memory compared to those without SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.