Evidence map›Paper›PMID 36373740›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Menstrual and Reproductive Factors in Association With Breast Cancer Risk in Vietnamese Women: A Case-Control Study.

Oanh Thi Bui, Huong Thanh Tran, Sang Minh Nguyen, Tu Van Dao, Quang Vinh Bui, Anh Tuan Pham, Martha J Shrubsole, Qiuyin Cai, Fei Ye, Wei Zheng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Systematic Review and Meta-Analysis of Lifestyle and Reproductive Factors Associated with Risk of Breast Cancer in Asian Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Oanh Thi BuiVietnam National Cancer Institute, National Cancer Hospital, Hanoi, Vietnam.ORCID 0000-0002-0850-759X
Huong Thanh TranVietnam National Cancer Institute, National Cancer Hospital, Hanoi, Vietnam.
Sang Minh NguyenDivision of Epidemiology, Department of Medicine, 219253Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-4338-8477
Tu Van DaoVietnam National Cancer Institute, National Cancer Hospital, Hanoi, Vietnam.ORCID 0000-0001-6858-8347
Quang Vinh BuiHanoi Oncology Hospital, Hanoi, Vietnam.
Anh Tuan PhamVietnam National Cancer Institute, National Cancer Hospital, Hanoi, Vietnam.ORCID 0000-0002-5961-1725
Martha J ShrubsoleDivision of Epidemiology, Department of Medicine, 219253Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, 219253Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Fei YeDepartment of Biostatistics, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, 219253Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Hung Nguyen LuuHillman Cancer Center, University of Pittsburgh Medical Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2172-1849
Thuan Van TranVietnam National Cancer Institute, National Cancer Hospital, Hanoi, Vietnam.ORCID 0000-0002-5839-0895
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, 219253Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, 12327Vanderbilt University School of Medicine, Nashville, TN, USA.
Vanderbilt University · USHanoi Medical University · VNVietnam National Children's Hospital · VNUPMC Hillman Cancer Center · US

Funding

TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
Vanderbilt-Emory-Cornell-Duke Global Health Fellowship Consortium-Expanding Diversity for Global Equity (EDGE)D43TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALIYU, MUKTAR HASSAN, HEIMBURGER, DOUGLAS CORBETT · 2017 to 2021
$6.3M
Regional Center of Research Excellence in Cancer and Other Non-Communicable Disease Epidemiology and Prevention in VietnamP20CA210300 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU, TRAN, THUAN · 2016 to 2017
$549k
FIC NIH HHS D43 TW009337NCI NIH HHS P20 CA210300NCI NIH HHS P50 CA098131
6 · The paper itself

Abstract

objectivesThough menstrual and reproductive factors have been associated with the risk of breast cancer in many populations, very few studies have been conducted among Vietnamese women. This study aimed to assess the association between menstrual and reproductive factors and the risk of breast cancer in Vietnamese women.

methodsA retrospective case-control study of 490 breast cancer cases and 468 controls was conducted in Northern Vietnam. Unconditional logistic regression models adjusting for confounders were used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations of menstrual and reproductive factors with the risk of breast cancer; overall and by cancer subtype.

resultsAmong breast cancer patients, the luminal B subtype was the most frequent (48.6%), followed by HER2-overexpressing (24.5%), luminal A (16.7%), and triple-negative breast cancer (TNBC; 10.2%). Among menopausal women, menopausal age at 50 years or older (OR = 1.71, 95% CI: 1.15-2.57 vs. <50 y) was associated with an increased risk of breast cancer. Earlier age at menarche (<13 y) was associated with a significantly increased risk of breast cancer (OR = 2.66, 95% CI: 1.08-7.51) among premenopausal women only and the luminal A subtype of breast cancer (OR = 3.06, 95% CI: 1.04-8.16). Having more than two children was associated with a reduced risk of premenopausal (OR = .42, 95%CI: .21-.83), luminal B (OR = .43, 95% CI: .24-.79), and TNBC (OR = .34, 95% CI: .14-.89). Later menopause was positively associated with the risk of breast cancer with HER2 overexpression (OR = 2.19, 95% CI: 1.14-4.23).

conclusionAssociations of menstrual and reproductive factors with breast cancer among Vietnamese women, particularly for among premenopausal women and for the luminal A subtype, are generally consistent with those reported from other countries. These findings suggest that changes in menstrual and reproductive patterns among young Vietnamese women may contribute to the recent rising incidence of breast cancer in Vietnam.

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsAsian PeopleCase-Control StudiesChildErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedReceptors, ProgesteroneRetrospective StudiesRisk FactorsVietnamErb-b2 Receptor Tyrosine KinasesReceptors, Progesteronebreast cancercase-control studymenstrual factorreproductive behaviorstumor subtype

Identifiers

PMID36373740
PMCPMC9663618
OpenAlexW4309163957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.