ArticleNucleic acids research2023
CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.
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Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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Who cites it
27 citing papers in PubMed.
- Searching the druggable genome using large language models.Bioinformatics (Oxford, England) · 2026Article
- Multiplatform curation in the development of ACMG/AMP specifications for Von Hippel-Lindau (VHL) disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- IDAP: an integrated literature- and knowledge-graph-driven evidence prioritization pipeline for precision oncology.Bioinformatics (Oxford, England) · 2026Article
- OncoRisk: a state-of-the-art web server for bridging the oncogenic databases and pan-cancer cohorts to the translational oncology.Communications biology · 2026Article
- The Knowledge Connector decision support system for multiomics-based precision oncology.Nature communications · 2026Article
- CancerStop.dev: an interactive web platform integrating prognostic data, clinical trials, and genomic resources for patient empowerment.Frontiers in digital health · 2026Article
- CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer.Bioinformatics advances · 2026Article
- Natural language processing of gene descriptions for overrepresentation analysis with GeneTEA.Genome biology · 2025Article
- CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer.bioRxiv : the preprint server for biology · 2025Article
- Genetic data normalization for genomic medicine: a Fast Healthcare Interoperability Resources Genomics reference implementation.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Evaluating Language Models for Biomedical Fact-Checking: A Benchmark Dataset for Cancer Variant Interpretation Verification.bioRxiv : the preprint server for biology · 2025Article
- Need Analysis of Clinician-Oriented Integrated Precision Oncology Decision Support Tools: Qualitative Descriptive Study.JMIR human factors · 2025Article
- Informatics at the Frontier of Cancer Research.Cancer research · 2025Review
- Detecting likely germline variants during tumor-based molecular profiling.The Journal of clinical investigation · 2025Review
- Decoding the functional impact of the cancer genome through protein-protein interactions.Nature reviews. Cancer · 2025Review
- EMBL's European Bioinformatics Institute (EMBL-EBI) in 2024.Nucleic acids research · 2025Article
- Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.Nature communications · 2025Article
- Strategies for the drug development of cancer therapeutics.Frontiers in pharmacology · 2025Review
- Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities.Biology of sex differences · 2024Article
- PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies.Genome medicine · 2024Article
Corrections and comments
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Authors and funding
65 authors.
Kilannin KrysiakDepartment of Pathology and Immunology, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6299-9230
Arpad M DanosMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Jason SalibaDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Joshua F McMichaelMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Adam C CoffmanMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0944-3126
Susanna KiwalaMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-4378-7328
Erica K BarnellMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Lana ShetaMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Cameron J GrisdaleCanada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Lynzey KujanMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Shahil PemaMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Jake LeverSchool of Computer Science, University of Glasgow, Glasgow, UK.
Sarah RiddDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Nicholas C SpiesMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Veronica AndricDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Andreea ChioreanDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Damian T RiekeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Kaitlin A ClarkMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Caralyn ReisleCanada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Ajay C VenigallaDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Mark EvansCaris Life Sciences, Phoenix, AZ, USA.
Payal JaniDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Hideaki TakahashiDepartment of Experimental Therapeutics/Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Avila SudaDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Peter HorakDepartment of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Deborah I RitterDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA.
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3979-8200
Benjamin J AinscoughMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Sean DelongLassonde School of Engineering, York University, Toronto, Ontario, Canada.
Chimene KesserwanDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA and Genetics Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Mario LampingCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Haolin ShenDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Alex R MarrDepartment of Pathology and Immunology, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
My H HoangDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Kartik SinghalDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Mariam KhanfarDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Brian V LiMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Wan-Hsin LinMayo Clinic Florida, Jacksonville, FL, USA.
Panieh TerrafDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Laura B CorsonDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Yasser SalamaDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Katie M CampbellMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6491-4432
Kirsten M FarncombeToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Jianling JiChildren's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4941-3538
Xiaonan ZhaoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Xinjie XuDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Rashmi Kanagal-ShamannaDepartment of Hematopathology and Molecular Diagnostics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ian KingDivision of Clinical Laboratory Genetics, Laboratory Medicine Program, University Health Network (UHN), Toronto, ON, Canada.
Kelsy C CottoDepartment of Medicine, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0890-6889
Zachary L SkidmoreMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Jason R WalkerMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Aleksandar MilosavljevicDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ronak Y PatelDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Rachel H GilesInternational Kidney Cancer Coalition, Duivendrecht-Amsterdam, the Netherlands.
Raymond H KimDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Sinai Health System, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Ontario Institute for Cancer Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Lynn M SchrimlUniversity of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8910-9851
Elaine R MardisThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Gordana RacaChildren's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Shruti RaoInnovation Center for Biomedical Informatics, Georgetown University Medical Center, WA DC, USA.
Subha MadhavanInnovation Center for Biomedical Informatics, Georgetown University Medical Center, WA DC, USA.
Alex H WagnerThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-2502-8961
Malachi GriffithMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6388-446X
Obi L GriffithMcDonnell Genome Institute, Washington University in St Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0843-4271
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MBaylor College of Medicine/Stanford University Clinical Genome Resource (CLINGEN)U24HG009649 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI TERI Ellen KLEIN, Aleksandar Milosavljevic · 2021 to 2026
$31.5MThe Clinical Genome Resource – Advancing genomic medicine through biocuration and expert assessment of genes and variants at scaleU24HG009650 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JONATHAN S BERG, Jessica Ezzell Hunter · 2021 to 2026
$30.0MStandardized and Genome-Wide Clinical Interpretation of Complex Genotypes for Cancer Precision MedicineU24CA237719 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, OBI L. · 2019 to 2023
$3.8MThe Human Disease Ontology: An integrated, mechanistic knowledge resource for biomedical research.U24HG012557 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI Lynn Marie Schriml · 2022 to 2026
$3.7MThe Disease Ontology Project: mechanistic profiles of human disease for biomedical and clinical researchU41HG008735 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHRIML, LYNN MARIE · 2017 to 2021
$3.4MIntegrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometryUH3TR002881 · NCATS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN, JONES, JENNIFER · 2021 to 2022
$1.9MDEVELOPMENT OF INFORMATICS RESOURCES FOR INTERPRETATION OF CLINICALLY ACTIONABLE VARIANTS IN CANCERU01CA209936 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, OBI L. · 2016 to 2018
$1.0MGenomic Expert Curation Panels for Pediatric MalignanciesU24CA258115 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI, GRIFFITH, OBI L. · 2022 to 2024
$870kTools for Normalizing and Interpreting the Clinical Actionability of Genomic VariantsR00HG010157 · NHGRI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WAGNER, ALEX HANDLER · 2021 to 2023
$727kIntegrated Analysis & Interpretation of Whole Genome Exome & Transcriptome SequenR00HG007940 · NHGRI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2017 to 2019
$724kNCATS NIH HHS UH3 TR002881NCATS NIH HHS UL1 TR002345NCI NIH HHS K22 CA188163NCI NIH HHS P30 CA008748NCI NIH HHS U01 CA209936NCI NIH HHS U24 CA237719NCI NIH HHS U24 CA258115NHGRI NIH HHS R00 HG007940NHGRI NIH HHS R00 HG010157NHGRI NIH HHS U24 HG009649NHGRI NIH HHS U24 HG009650NHGRI NIH HHS U24 HG012557NHGRI NIH HHS U41 HG008735
Abstract
CIViC (Clinical Interpretation of Variants in Cancer; civicdb.org) is a crowd-sourced, public domain knowledgebase composed of literature-derived evidence characterizing the clinical utility of cancer variants. As clinical sequencing becomes more prevalent in cancer management, the need for cancer variant interpretation has grown beyond the capability of any single institution. CIViC contains peer-reviewed, published literature curated and expertly-moderated into structured data units (Evidence Items) that can be accessed globally and in real time, reducing barriers to clinical variant knowledge sharing. We have extended CIViC's functionality to support emergent variant interpretation guidelines, increase interoperability with other variant resources, and promote widespread dissemination of structured curated data. To support the full breadth of variant interpretation from basic to translational, including integration of somatic and germline variant knowledge and inference of drug response, we have enabled curation of three new Evidence Types (Predisposing, Oncogenic and Functional). The growing CIViC knowledgebase has over 300 contributors and distributes clinically-relevant cancer variant data currently representing >3200 variants in >470 genes from >3100 publications.
Indexed as
Genetic VariationNeoplasmsHigh-Throughput Nucleotide SequencingHumansKnowledge Bases
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