Evidence map›Paper›PMID 36373223›Full record

ArticleJournal of internal medicine2023

Post-COVID-19 condition in the German working population: A cross-sectional study of 200,000 registered stem cell donors.

Stefanie N Bernas, Henning Baldauf, Ruben Real, Jürgen Sauter, Jan Markert, Sarah Trost, Kristin Tausche, Uta Behrends, Alexander H Schmidt, Johannes Schetelig

Open access · hybridAbstract read
In one paragraph

Article in Journal of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Prevalence and symptoms of Long Covid-19 in the workplace.Occupational medicine (Oxford, England) · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Stefanie N BernasDKMS, Stem Cell Donor Registry, Tübingen, Germany.ORCID 0000-0002-9700-6710
Henning BaldaufDKMS, Clinical Trials Unit, Dresden, Germany.
Ruben RealDKMS, Clinical Trials Unit, Dresden, Germany.
Jürgen SauterDKMS, Stem Cell Donor Registry, Tübingen, Germany.
Jan MarkertDKMS, Stem Cell Donor Registry, Tübingen, Germany.
Sarah TrostDKMS, Clinical Trials Unit, Dresden, Germany.
Kristin TauscheDivision of Pulmonology, Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Uta BehrendsSchool of Medicine, Department of Pediatrics, MRI Chronic Fatigue Center for Young People, Technical University of Munich, Munich, Germany.
Alexander H SchmidtDKMS, Stem Cell Donor Registry, Tübingen, Germany.ORCID 0000-0003-0979-5914
Johannes ScheteligDKMS, Clinical Trials Unit, Dresden, Germany.
German National Bone Marrow Donor Registry · DEDeutsche Knochenmarkspenderdatei · DEUniversity Hospital Carl Gustav Carus · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe SARS-CoV-2 pandemic has strained health systems worldwide, and infection numbers continue to rise. While previous data have already shown that many patients suffer from symptoms for months after an acute infection, data on risk factors and long-term outcomes are incomplete, particularly for the working population.

objectivesWe aimed to provide information on the prevalence of post-COVID-19 conditions in a subset of the German working-age population (18-61 years old) and to analyze risk factors.

methodsWe conducted an online survey with a health questionnaire among registered potential stem cell donors with or without a self-reported history of polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection. Logistic regression models were used to examine the risks of severity of acute infection, sex, age, body mass index, diabetes mellitus, and arterial hypertension medication on post-COVID-19 symptoms.

resultsA total of 199,377 donors reported evaluable survey questionnaires-12,609 cases had a history of SARS-CoV-2 infection and 186,768 controls had none. Overall, cases reported physical, cognitive, and psychological complaints more frequently compared to controls. Increased rates of complaints persisted throughout 15 months postinfection, for example, 28.4%/19.3% of cases/controls reported fatigue (p <0.0001) and 9.5%/3.6% of cases/controls reported loss of concentration (p <0.0001). No significant differences were observed in the frequency of reported symptoms between 3 and 15 months postinfection. Multivariate analysis revealed a strong influence of the severity of the acute SARS-CoV-2 infection episode and age on the risk for post-COVID-19 conditions.

conclusionWe report the prevalence of post-COVID-19 conditions in mainly unvaccinated individuals with SARS-CoV-2 infections between February 2020 and August 2021. The severity of the acute course and age were major risk factors. Vaccinations may reduce the risk of post-COVID-19 conditions by reducing the risk of severe infections.

Indexed as

COVID-19AdolescentAdultCross-Sectional StudiesHumansMiddle AgedRisk FactorsSARS-CoV-2Stem CellsYoung AdultCOVID-19long COVIDpost-COVID-19 conditionSARS-CoV-2survey

Identifiers

PMID36373223
PMCPMC10107314
OpenAlexW4309094674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.