Evidence map›Paper›PMID 36372970›Full record

ArticleMagnetic resonance in medicine2023

Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in

Joseph W Plummer, Matthew M Willmering, Zackary I Cleveland, Christopher Towe, Jason C Woods, Laura L Walkup

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025
    Article
  6. Article
  7. Article
  8. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  9. Article
  10. Observational
  11. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  12. Article
  13. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph W PlummerCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-0200-7869
Matthew M WillmeringCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-4356-9622
Zackary I ClevelandCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-6195-9061
Christopher ToweDepartment of Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Jason C WoodsCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-8080-7511
Laura L WalkupCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-5060-6401

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
Early detection of regional BOS in BMT patients using UTE and 129Xe MRIR00HL138255 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WALKUP, LAURA LEE · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL138255NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R01 HL151588NHLBI NIH HHS R44 HL123299NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

purposeXenon-129 ( THEORY: We model healthy reference values for

methodsVentilation, membrane-uptake, red blood cell transfer, and red blood cell:membrane gas-exchange metrics were collected on 30 healthy subjects over an age range of 5 to 68 years. A GAMLSS model was fit against age and compared against widely used linear and generalized-linear binning

resultsAll 4 gas-exchange metrics had significant skewness, and membrane-uptake had significant kurtosis compared to a normal distribution. Age has significant impact on distribution parameters. GAMLSS-binning produced narrower bins compared to the linear and generalized-linear binning schemes and distributed signal data closer to a normal distribution.

conclusionThe proposed "proof-of-concept" GAMLSS-binning approach can improve diagnostic accuracy of

Indexed as

LungMagnetic Resonance ImagingAdolescentAdultAgedChildChild, PreschoolErythrocytesHumansMiddle AgedRespirationRespiratory Function TestsXenon IsotopesYoung AdultXenon Isotopes129Xe MRIage dependenceGAMLSSgas exchangehealthy-reference distributionspulmonary imaging

Identifiers

PMID36372970
PMCPMC9792434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.