ArticleBJOG : an international journal of obstetrics and gynaecology2023
Different pathways for preterm birth between singleton and twin pregnancies: a population-based registry study of 481 176 nulliparous women.
Article in BJOG : an international journal of obstetrics and gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Donor human milk versus infant formula for low-risk infants: a systematic review.Pediatric research · 2025Pooled it
- Twin pregnancy and postpartum haemorrhage: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2023Pooled it
- Cervical pessary versus vaginal progesterone in women with a multiple pregnancy and a short cervix: A randomised controlled trial.PLoS medicine · 2025Trial
- Distinct birth size and postnatal growth patterns in preterm twins and singletons: an etiology-based analysis from the INTERPRACTICE-21Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Industrial emissions and risks of preterm and small-for-gestational-age birth: A population-based cohort study in Quebec, Canada.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Persistence of antenatal anti-D immunoglobulin G at delivery in twin versus singleton pregnancies: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Predictive value of a short cervix in the early third trimester for preterm birth in twin pregnancies.BMC pregnancy and childbirth · 2026Article
- Immune landscape of the affected brain in Rasmussen encephalitis.Scientific reports · 2026Article
- Prevalence and risk factors of adverse birth outcomes in Bangladesh: Insight from a nationwide survey.PloS one · 2026Article
- Association of adverse pregnancy outcomes and intimate partner violence survivorship: a cross-sectional survey.Frontiers in global women's health · 2026Article
- Temporal trends and factors associated with live preterm births in Espírito Santo, 2012-2021.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026Article
- Prediction of spontaneous preterm birth before 34 weeks in twin pregnancies using first-trimester cervical length.BMC pregnancy and childbirth · 2025Article
- Neutrophil-To-Lymphocyte Ratio and Delivery Within 24 h in Preterm Premature Rupture of Membranes: A Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Factors influencing participation in home, school, and community settings by 6- to 9-year-old children born preterm: a qualitative descriptive study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Article
- Trends and adverse pregnancy outcomes associated with preeclampsia: a multi-centre cross-sectional study in Hebei, China.BMC pregnancy and childbirth · 2025Article
- Delaying Motherhood-An Increasingly Common but Risky Trend in High-Income Countries.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Early childhood weight trajectory differences in twins, singletons, and gestational-age matched singletons.Preventive medicine reports · 2025Article
- Factors influencing sex ratio at birth in Krosno, Poland.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo explore the contribution of pregnancy-related complications on the prevalence of extremely, very and late preterm births in singleton and twin pregnancies. To study the risk of spontaneous preterm birth in twin pregnancies compared with singleton pregnancies.
designPopulation-based registry study.
settingMedical birth registry of Norway and Statistics Norway. POPULATION: Nulliparous women with singleton (n = 472 449) or twin (n = 8727) births during 1999-2018.
methodsPrevalence rates of pregnancy-related complications for extremely, very and late preterm birth in twin and singleton pregnancies were calculated with 95% confidence intervals. Multivariable logistic regression was applied to assess odds ratios for preterm birth, adjusted for obstetric and socio-economic factors.
main outcome measuresExtremely preterm (<28
resultsPreterm birth was significantly more prevalent in twin pregnancies than in singleton pregnancies in all categories: all preterm (54.7% vs 6.1%), extremely preterm (3.6% vs 0.4%), very preterm (18.2% vs 1.4%) and late preterm (33.0% vs 4.3%) births. Stillbirth, congenital malformation and pre-eclampsia were more prevalent in twin pregnancies than in singleton pregnancies, but the prevalence of complications differed in the three categories of preterm birth. Pre-eclampsia was more prevalent in singleton than in twin pregnancies ending in extremely and very preterm birth. The adjusted odds of spontaneous preterm live birth were between 19- and 54-fold greater in twin pregnancies than in singleton pregnancies.
conclusionsSingleton and twin pregnancies seem to have different pathways leading to extremely, very and late preterm birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.